- Basic information
- CohesinDB ID: CDBP00420352
- Locus: chr21-42456477-42457076
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Data sourse: GSE86191, GSE67783, ENCSR153HNT, GSE68388
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Cell type: K-562, HCT-116, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 40%,
"7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MYCN, POU5F1, ZFX, ZNF317, SMAD3, ZBTB48, WT1, FOXA1, SRF, ERG3, ZBTB33, ERG2, ZFHX2, YY1, HDGF, MYC, ZNF610, SP140, ZIC2, GABPA, MAX, FOS, MITF, JMJD1C, NCOA3, TERF1, KMT2A, MLLT1, STAG1, TP53, PKNOX1, EGR2, CTCF, SPI1, AR, REST, ZBTB7A, EGR1, FLI1, HSF1, BRD4, MAZ, MRTFB, ZNF24, EHMT2
- Target gene symbol (double-evidenced CRMs): ABCG1,SLC37A1,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000177398,
ENSG00000160179,
ENSG00000160190,
- Related loop:
chr21:41600000-41625000~~chr21:42450000-42475000,
chr21:42125000-42150000~~chr21:42450000-42475000,
chr21:42144666-42146603~~chr21:42449091-42451494,
chr21:42144929-42146574~~chr21:42449093-42451498,
chr21:42144930-42146490~~chr21:42449278-42451482,
chr21:42150000-42175000~~chr21:42450000-42475000,
chr21:42300000-42325000~~chr21:42450000-42475000,
chr21:42308432-42311039~~chr21:42449093-42451498,
chr21:42308453-42310909~~chr21:42449091-42451494,
chr21:42308479-42311031~~chr21:42449017-42451480,
chr21:42308481-42310631~~chr21:42449278-42451482,
chr21:42337150-42338850~~chr21:42449091-42451494,
chr21:42376206-42377802~~chr21:42449017-42451480,
chr21:42380717-42382804~~chr21:42449093-42451498,
chr21:42380793-42382292~~chr21:42449091-42451494,
chr21:42380903-42382335~~chr21:42449017-42451480,
chr21:42450000-42475000~~chr21:42550000-42575000,
chr21:42454707-42456121~~chr21:42535463-42538505,
chr21:42454756-42455941~~chr21:42536154-42538496,