Deatailed information for cohesin site CDBP00420357

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  • Basic information
  • CohesinDB ID: CDBP00420357
  • Locus: chr21-42464964-42468175
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE25021, ENCSR000EGW, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE73207, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE138405, GSE86191, GSE93080, GSE76893, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE118494, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR620NWG, GSE62063, ENCSR767DFK, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE38395, GSE55407, ENCSR944ZCT, GSE131956, GSE110061, GSE129526, GSE111913, GSE155324, GSE38411, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577
  • Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, Ramos, GM19238, HeLa, OCI-AML-3, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 45% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.344
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TES,Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 88% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 35%, "5_TxWk": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, SOX2, MEIS2, XBP1, HNF1A, TBL1X, FOXA1, RBFOX2, PBX2, OGG1, MLL4, ZFHX2, TFAP4, HDGF, LYL1, ATF3, BMI1, NFIC, THAP1, RUNX3, CHD7, ATF4, CBFB, ZNF189, SMARCE1, PAX5, MECOM, ZNF320, BACH2, CDX2, ZNF467, JMJD1C, MYOG, KLF5, ELF1, BCLAF1, TRIM28, RBM39, SNAI2, TEAD1, ETV1, ZNF217, LMO2, ESR1, SMAD5, OCA2, HNF1B, NFE2L2, USF2, ZNF561, CTCF, TCF12, SND1, EP300, ARID5B, BAF155, LMO1, E4F1, GATA6, MNT, PAX8, DPF2, KLF1, E2F6, IRF4, TRIM24, SOX6, PRKDC, RAD51, DDX20, E2F1, ZNF528, TEAD4, KMT2B, ZNF175, GTF2F1, PDX1, TFAP2C, EED, RBPJ, YBX1, EHMT2, POU2F2, CHD8, NANOG, ZNF263, POU5F1, CDK7, ID3, MYCN, CTBP1, MTA2, ZBTB17, ZBTB48, RUNX1T1, STAT1, ELK4, ZNF205, SRF, ASH1L, ZSCAN5A, NBN, ARID3A, TBP, HNF4G, ERG, PBX1, ASCL1, ZNF597, ZNF341, ETS1, MYC, ONECUT1, SMARCA4, RFX1, EOMES, RAD21, ARID1B, GRHL3, EZH1, PROX1, RXRA, GABPA, STAT3, APC, XRCC5, NKX3-1, IKZF1, RCOR1, TERF2, DACH1, NFKB2, ZNF639, NFE2, NR3C1, CEBPB, SRSF3, ESRRA, NR2F6, VDR, KMT2A, CREB1, EZH2, TBL1XR1, GRHL2, GABPB1, ZHX2, SPI1, HES1, HDAC2, GATA2, GATAD2B, SIX2, ZSCAN29, FLI1, HCFC1, MXI1, SMARCA5, RELB, MRTFB, NFYB, ATF1, PTBP1, RUNX1, BCL6, SMC1A, CBX1, NKX2-2, HDAC1, IRF3, CEBPA, ZFX, MTA3, LDB1, ERG3, TRIM22, SMARCC1, PRDM10, MEF2A, CREBBP, NFYC, NOTCH1, BRD9, RUNX2, SMAD2, GATA4, ZNF184, ARNT, BACH1, PBX4, ATF2, HMBOX1, SMAD4, NFYA, ETV6, FOXM1, CBFA2T3, FOS, SUPT5H, SP2, PBX3, CDK8, MED1, NR2C1, ZEB1, TERF1, PML, MYB, CEBPD, DIDO1, SMAD1, VEZF1, TAF7, ZNF3, ZMYM3, NCOA1, L3MBTL2, EVI1, STAT5A, KLF16, MAFK, SP1, BCL11A, NIPBL, HNF4A, USF1, REST, ZBTB7A, JUN, RBM25, ATF7, POU2F3, ASH2L, HNRNPLL, PHIP, BCOR, TCF3, FOXP1, MBD2, SMC3, NCOR2, STAG1, MLLT1, NFATC3, SKI, CBFA2T2, MEF2B, PPARG, CBX3, ZNF207, EBF1, CREM, SS18, RBBP5, CHD2, FOXA2, GTF2B, WT1, MEIS1, E2F8, ZBED1, ZBTB33, MEF2C, CDK9, HOXB13, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, ZEB2, ZNF148, NEUROD1, JUNB, SP140, TCF4, SKIL, ZFP36, ZIC2, BHLHE22, GATA3, OTX2, ZNF519, MGA, TAL1, MAX, BATF, SPIB, ZNF143, GATA1, NRIP1, HAND2, PLAG1, KLF4, BCL11B, ZNF592, GFI1B, NR2F2, NCOA3, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, IRF5, ZNF334, NFKB1, MYOD1, PHOX2B, ELF3, T, BRD2, TBX21, BHLHE40, AR, ZNF445, ZBTB16, ZBTB40, RXR, ZNF324, EGR1, RB1, HSF1, RNF2, IKZF2, BRD4, NCOR1, JUND, CLOCK, MAZ, IRF9, TBX2, MEF2D, AHR
  • Target gene symbol (double-evidenced CRMs): UMODL1,ABCG1,RSPH1,SLC37A1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 19
  • Related genes and loops
  • Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160188, ENSG00000160190,
  • Related loop: chr21:41600000-41625000~~chr21:42450000-42475000, chr21:42125000-42150000~~chr21:42450000-42475000, chr21:42150000-42175000~~chr21:42450000-42475000, chr21:42300000-42325000~~chr21:42450000-42475000, chr21:42450000-42475000~~chr21:42550000-42575000, chr21:42466723-42468288~~chr21:42517954-42519108, chr21:42466723-42468288~~chr21:42536785-42538249, chr21:42466738-42468349~~chr21:42512702-42515312, chr21:42466738-42468349~~chr21:42536098-42538505, chr21:42466750-42468364~~chr21:42534380-42538530, chr21:42466752-42469410~~chr21:42536796-42538220, chr21:42466778-42468284~~chr21:42536154-42538496, chr21:42466880-42468218~~chr21:42535463-42538505,
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