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Basic information

CohesinDB ID: CDBP00420363

Locus: chr21-42473712-42475050

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, GSE86191, GSE138405, ENCSR703TNG, GSE94872, ENCSR000BLS, GSE85526, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR853VWZ, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS

Cell type: GM2610, GM19240, Liver, HuCC-T1, H9-hESC, HEKn, Ishikawa, HeLa-S3, GM2255, K-562, GM18486, DKO, SNYDER, GM12878, GM2588, SK-N-SH, GM19239, RT-112, THP-1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.667

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 32%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZNF660, HMGN3, HNF1A, XBP1, PATZ1, FOXA1, SUZ12, RXRB, OGG1, MLL4, ZFHX2, TFAP4, HDGF, THRB, ZC3H8, ATF3, ZFP64, CHD7, PRDM1, RUNX3, ZNF444, KLF14, MXD4, ZNF189, PAX5, TP63, ZNF736, CDX2, ZNF467, KLF5, ELF1, TEAD1, BCLAF1, KLF6, ETV1, LMO2, ESR1, USF2, CTCF, TCF12, JUN, BAF155, EP300, SOX9, GATA6, SOX5, DPF2, DMAP1, TRIM24, RFX5, DEK, E2F4, RAD51, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, TFAP2C, EED, GLIS1, PDX1, NANOG, POU2F2, POU5F1, MYCN, ZNF263, KDM4C, ID3, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN5A, ZSCAN21, STAT1, ZBTB1, SRF, GATAD1, SAP130, NBN, ERG2, SP4, ARID3A, DDX5, HNF4G, HOXC5, ERG, ZNF597, SMARCC2, ETS1, MYC, ZNF341, NFKB2, KDM4A, RFX1, HOMEZ, RAD21, GRHL3, RXRA, PROX1, NKX2-1, GABPA, APC, XRCC5, STAT3, NKX3-1, ZNF398, IKZF1, MIER3, RCOR1, NR2F6, CREM, VDR, PRDM14, NR3C1, CEBPB, ESRRA, DNMT3B, CREB1, ZBTB11, TBL1XR1, EZH2, BMPR1A, GRHL2, ZNF652, EBF3, GABPB1, ZHX2, SPI1, EHF, IRF1, KLF17, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, FLI1, HCFC1, ZGPAT, MXI1, RELB, NFIL3, MRTFB, NCOA2, ZIM3, ETV5, RUNX1, THAP11, CTNNB1, MAFG, BCL6, CBX1, CEBPA, NKX2-2, SMC1A, SOX13, SIN3A, AFF4, ZNF534, ZFX, SMAD3, ZNF770, TET2, ERG3, SP5, TRIM22, SMARCC1, PRDM10, RARA, PRPF4, CREBBP, ZNF35, ZBTB2, ZNF384, RUNX2, CDK6, GATA4, ZNF184, GR, SP3, ARNT, DAXX, PBX4, CBX3, NRF1, ZNF48, PRDM9, SMAD4, SP2, SMARCB1, CDK8, HMGXB4, FOS, CHD1, MED1, ZEB1, TEAD3, SPDEF, TERF1, KDM6B, PIAS1, NR1H2, C11orf30, MAFK, NIPBL, SP1, BCL11A, HNF4A, ARID1A, ZBTB7A, ZHX1, ATF7, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, BCOR, AATF, SMC3, NCOR2, STAG1, MLLT1, ETV4, NFATC3, SKI, AGO1, TRP47, CBFA2T2, MEF2B, PPARG, TBL1X, ZNF207, FOXA2, CHD2, SS18, PAF1, MIER2, ZNF600, ZNF692, MAFF, WT1, EBF1, E2F8, ZNF574, ZNF580, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, AHR, BRG1, MCM3, SP140, ZIC2, TCF4, HIF1A, PCGF1, SKIL, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, HAND2, PLAG1, KLF4, CEBPG, SP7, NCOA3, NR2F2, ZNF281, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZNF687, ZNF334, NFKB1, ZSCAN22, EGR2, ELF3, BRD2, KAT8, T, TBX21, ARID4B, AR, BHLHE40, RXR, EGLN2, ZBTB42, HEXIM1, RB1, EGR1, HSF1, ZBTB26, NCOR1, BRD4, JUND, IKZF2, CLOCK, MAZ, BRCA1, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): ABCG1,RSPH1,C2CD2,SLC37A1,PRDM15,UMODL1,BACE2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 14

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000182240, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420363