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Basic information

CohesinDB ID: CDBP00420365

Locus: chr21-42478322-42479169

Data sourse: GSE93080, ENCSR000EAC, ENCSR000DZP, ENCSR000BMY, GSE50893

Cell type: GM12892, GM2630, SNYDER, GM18505, GM2610, GM19240, GM12878, GM12891, GM2588, GM12890, GM19238, GM19099, GM19239, GM19193, GM18486

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 57%, "14_ReprPCWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, CBX5, PGR, SOX2, NME2, XBP1, FOXA1, HLF, ZFHX2, HDGF, LYL1, BMI1, NFIC, ATF3, RUNX3, PRDM1, CBFB, ZNF189, MECOM, PAX5, ZSCAN4, TP63, BACH2, CDX2, JMJD1C, ELF1, BCLAF1, TRIM28, SNAI2, ZNF217, ESR1, LMO2, OCA2, USF2, CTCF, TCF12, JUN, EP300, BAF155, LMO1, GATA6, DPF2, IRF4, RAD51, ZNF528, TEAD4, PDX1, RBPJ, EED, POU2F2, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, BRD3, TOP2A, MTA2, ZBTB48, STAT1, NBN, ARID3A, ERG2, HNF4G, ERG, OGG1, MYC, ONECUT1, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, IKZF1, NR3C1, CEBPB, CREB1, EZH2, GRHL2, SPI1, IRF1, HDAC2, GATA2, GATAD2B, FLI1, SMARCA5, ZNF766, RELB, RUNX1, SMC1A, BCL6, MAFG, NKX2-2, CEBPA, CRY1, ZFX, POU4F2, SMAD3, ERG3, CBX8, TRIM22, SMARCC1, CREBBP, ZBTB2, NOTCH1, ZNF384, ZNF35, CDK6, GATA4, ARNT, BACH1, PBX4, ATF2, PRDM9, FOXM1, PBX3, MAFB, FOS, CDK8, MED1, MYB, SCRT2, PIAS1, C11orf30, EVI1, MAFK, NIPBL, BCL11A, SP1, ARID1A, ATF7, POU2F3, HNRNPLL, TCF3, FOXP1, SMC3, MLLT1, STAG1, NFATC3, MEF2B, ZNF316, CREM, EBF1, E2F8, WT1, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF267, MCM3, SP140, TCF4, SKIL, ZFP36, BHLHE22, BATF, TAL1, MAX, SPIB, ZNF143, CBX2, KLF4, ZNF592, BCL11B, NCOA3, ZNF687, PKNOX1, ZNF140, EGR2, ELF3, TBX21, BHLHE40, AR, ZBTB16, ZBTB40, RNF2, IKZF2, BRD4, JUND, SCRT1, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): PRDM15,SLC37A1,UMODL1,BACE2,C2CD2,RSPH1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000182240, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420365