- Basic information
- CohesinDB ID: CDBP00420368
- Locus: chr21-42485826-42486174
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Data sourse: GSE67783, GSE111913, ENCSR153HNT, GSE86191
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Cell type: K-562, RT-112, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 47%,
"14_ReprPCWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, CBX5, PGR, SOX2, NME2, XBP1, FOXA1, HLF, ZFHX2, HDGF, LYL1, BMI1, NFIC, ATF3, RUNX3, PRDM1, CBFB, ZNF189, MECOM, PAX5, ZSCAN4, TP63, BACH2, CDX2, JMJD1C, ELF1, BCLAF1, TRIM28, SNAI2, ZNF217, ESR1, LMO2, OCA2, USF2, CTCF, TCF12, JUN, EP300, BAF155, LMO1, GATA6, DPF2, IRF4, RAD51, ZNF528, TEAD4, PDX1, RBPJ, EED, POU2F2, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, BRD3, TOP2A, MTA2, ZBTB48, STAT1, NBN, ARID3A, ERG2, HNF4G, ERG, OGG1, MYC, ONECUT1, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, IKZF1, NR3C1, CEBPB, CREB1, EZH2, GRHL2, SPI1, IRF1, HDAC2, GATA2, GATAD2B, FLI1, SMARCA5, ZNF766, RELB, RUNX1, SMC1A, BCL6, MAFG, NKX2-2, CEBPA, CRY1, ZFX, POU4F2, SMAD3, ERG3, CBX8, TRIM22, SMARCC1, CREBBP, ZBTB2, NOTCH1, ZNF384, ZNF35, CDK6, GATA4, ARNT, BACH1, PBX4, ATF2, PRDM9, FOXM1, PBX3, MAFB, FOS, CDK8, MED1, MYB, SCRT2, PIAS1, C11orf30, EVI1, MAFK, NIPBL, BCL11A, SP1, ARID1A, ATF7, POU2F3, HNRNPLL, TCF3, FOXP1, SMC3, MLLT1, STAG1, NFATC3, MEF2B, ZNF316, CREM, EBF1, E2F8, WT1, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF267, MCM3, SP140, TCF4, SKIL, ZFP36, BHLHE22, BATF, TAL1, MAX, SPIB, ZNF143, CBX2, KLF4, ZNF592, BCL11B, NCOA3, ZNF687, PKNOX1, ZNF140, EGR2, ELF3, TBX21, BHLHE40, AR, ZBTB16, ZBTB40, RNF2, IKZF2, BRD4, JUND, SCRT1, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): RSPH1,BACE2,PRDM15,UMODL1,C2CD2,SLC37A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160188,
ENSG00000160190,
- Related loop:
chr21:41200000-41225000~~chr21:42475000-42500000,
chr21:41650000-41675000~~chr21:42475000-42500000,
chr21:41700000-41725000~~chr21:42475000-42500000,
chr21:41800000-41825000~~chr21:42475000-42500000,
chr21:41900000-41925000~~chr21:42475000-42500000,
chr21:41950000-41975000~~chr21:42475000-42500000,
chr21:42125000-42150000~~chr21:42475000-42500000,
chr21:42475000-42500000~~chr21:42575000-42600000,
chr21:42475000-42500000~~chr21:43250000-43275000,
chr21:42475000-42500000~~chr21:43300000-43325000,