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Basic information

CohesinDB ID: CDBP00420371

Locus: chr21-42494711-42497356

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, GSE115602, ENCSR000BTU, GSE165895, ENCSR000DZP, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE106870, GSE116344, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR000EHW, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, ENCSR000EHX, ENCSR495WGO, GSE97394, ENCSR000BTQ, GSE38395, ENCSR853VWZ, GSE129526, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR000ECS, GSE64758, GSE38411

Cell type: RH4, GM10847, GM2610, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Ramos, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 30% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.400

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 27%, "1_TssA": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, MLL4, KDM3A, HDGF, THAP1, IKZF3, PAX5, TEAD1, LMO2, OCA2, PITX3, HDAC8, E4F1, ARID5B, SOX5, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, CTBP1, STAT1, SAP130, ERG, ZBTB21, EZH1, SMARCA4, RFX1, TOP1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, RELB, RUNX1, CEBPA, HDAC1, NKX2-2, IRF3, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ELK1, ATF2, FOXM1, SP2, SMARCB1, PIAS1, STAT5A, ARID2, IKZF5, RBM25, AFF1, MBD2, ELL2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, SS18, BRF2, WT1, DEAF1, NEUROD1, TCF4, ZFP36, MAF1, ZNF333, PLAG1, KLF4, BCL11B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ADNP, FOSL1, XBP1, PBX2, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, ZNF467, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, IRF4, DDX20, PDX1, RBPJ, TFAP2C, MLX, ZSCAN21, ZBTB17, ZBTB48, ZNF317, SRF, NBN, KDM4A, HOMEZ, NKX3-1, MIER3, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, NFIL3, THAP11, CIITA, ZBTB24, AFF4, SOX13, POU4F2, ZNF770, SP3, ARNT, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, MAFB, HMGXB4, TEAD3, ZXDB, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG2, MLLT1, STAG1, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, ZNF143, TP53, ZNF334, ZSCAN22, NFKB1, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, PGR, SOX2, PATZ1, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, KLF6, NFE2L2, ZNF217, SAP30, ESR1, KLF1, SOX4, E2F6, TRIM24, RFX5, PRKDC, U2AF2, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ELK4, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, GABPA, STAT3, IKZF1, EZH2, MRTFA, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, NFYB, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, CREBBP, RARA, NFYC, ZNF384, TAF15, ZNF35, SMAD4, CDK8, CSNK2A1, ZEB1, ZMYM3, SREBF2, RBM22, MAFK, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, RELA, TARDBP, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, YAP1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, EED, ATRX, CHD8, BRD1, MYCN, RUNX1T1, CDK7, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, TFE3, EHF, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZNF534, ZFX, SMAD3, NOTCH1, RUNX2, CDK6, GATA4, NRF1, PBX4, FOS, CHD1, MED1, RFX2, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, OTX2, ZNF519, GATA1, HAND2, CEBPG, SP7, NCOA3, ZNF687, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): UMODL1,SLC37A1,RSPH1,PRDM15,BACE2,C2CD2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 38

Number of somatic mutations (non-coding): 27

Related genes and loops

Related gene: ENSG00000182240, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420371