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Basic information

CohesinDB ID: CDBP00420375

Locus: chr21-42502708-42504189

Data sourse: GSE62063, ENCSR000BMY, ENCSR153HNT, GSE73207

Cell type: K-562, TF-1, GM12878, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: NIPBL,SA1,Rad21,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 53%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, SUZ12, HDGF, LYL1, NFIC, RUNX3, PRDM1, CBFB, MECOM, PAX5, JMJD1C, ELF1, TRIM28, BCLAF1, LMO2, CTCF, TCF12, IRF4, GTF2F1, EED, POU2F2, RUNX1T1, ID3, CDK7, STAT1, ERG, ETS1, MYC, RFX1, GABPA, NFE2, KMT2A, GABPB1, SPI1, GATA2, ZNF777, FLI1, RUNX1, BCL6, CEBPA, LDB1, ZFX, CBX8, TRIM22, MEF2A, ZBTB2, ZNF384, NOTCH1, ARNT, ETV6, FOXM1, CDK8, MED1, TERF1, ZNF558, MYB, SMAD1, EVI1, BCL11A, SP1, NR4A1, ZBTB7A, ASH2L, TCF3, STAG1, MEF2B, CREM, EBF1, GTF2B, KDM1A, YY1, RELA, GATA3, BATF, TAL1, GATA1, HAND2, PLAG1, BCL11B, GFI1B, TCF7L2, ZBTB16, HSF1, BRD4, AHR

Target gene symbol (double-evidenced CRMs): PRDM15,ABCG1,UBASH3A,SLC37A1,TMPRSS3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000141956, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160190,

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Deatailed information for cohesin site CDBP00420375