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Basic information

CohesinDB ID: CDBP00420381

Locus: chr21-42520617-42521491

Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE25021, GSE131606, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR198ZYJ, GSE145327, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR167MTG, ENCSR054FKH, ENCSR153HNT

Cell type: H1-hESC, Fibroblast, HCT-116, Hep-G2, Neurons-H1, DKO, HUES64, CNCC-WT33iPSC, SK-N-SH, K-562, Liver, Macrophage, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 39%, "4_Tx": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, MLL4, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, ZNF561, ARID5B, DEK, E2F4, ZNF674, ZNF528, NR5A2, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, CTBP1, ERF, DUX4, STAT1, ERG, ZBTB8A, EZH1, SMARCA4, TOP1, RCOR1, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, KLF17, GATA2, MXD3, FLI1, HCFC1, NR2C2, MXI1, RELB, RUNX1, HDAC1, CEBPA, IRF3, NKX2-2, REPIN1, TET2, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, NR1H2, ARID2, IKZF5, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, SS18, WT1, JUNB, NEUROD1, ZFP36, TCF4, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, ZNF101, ATF3, ZC3H8, ZFP64, RUNX3, WDHD1, CBFB, ZNF273, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, TAF3, JUN, ZBTB20, LMO1, MNT, RYBP, DPF2, SIX5, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, DDX5, NBN, KDM4A, ZNF2, NKX3-1, PRDM14, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, ZKSCAN5, KDM5A, ZBTB14, ZSCAN29, SMARCA5, EZH2phosphoT487, AFF4, SOX13, SP3, DAXX, BACH1, ARNT, NFIB, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ETV6, TEAD3, ZXDB, KLF9, USF1, BCL11A, TFAP2A, SP1, NKX2-5, ATF7, ASH2L, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, ZNF334, NFKB1, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, SPIN1, JUND, CUX1, ZSCAN23, PGR, FANCL, SOX2, PATZ1, RING1B, UBTF, TFAP4, BMI1, CHD7, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, TP73, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ZNF24, KLF12, NKX2-1, GABPA, STAT3, IKZF1, INO80, DNMT3B, EZH2, PHF8, SPI1, ZNF202, HDAC2, INTS13, GATAD2B, NCOA2, ZNF76, ETV5, BCL6, SIN3A, ZFP37, ERG3, RARA, ZNF35, ZNF384, CREBBP, TAF15, CDK8, CSNK2A1, ZEB1, NCOA1, SREBF2, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, RELA, TARDBP, SKIL, MAX, ZNF223, BAP1, NR2F1, TCF7L2, KDM5B, PKNOX1, AR, PAX3-FOXO1, ZNF324, HEXIM1, AHR, DMAP1, MBD3, FOSL2, ZNF391, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF90, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ARID3A, USP7, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, TFE3, EHF, ZNF664, IRF1, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, SMAD3, CBX8, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, ZNF184, OSR2, GR, NRF1, PBX4, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, PAX7, ZNF283, FOXA2, RBBP5, E2F8, ZNF600, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, ZNF449, GATA1, TLE3, SP7, NCOA3, NR2F2, ZNF687, ZNF213, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): UBASH3A,ABCG1,TMPRSS3,PRDM15,SLC37A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 10

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000141956, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420381