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Basic information

CohesinDB ID: CDBP00420386

Locus: chr21-42528891-42529866

Data sourse: GSE62063, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: NIPBL,SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 59%, "14_ReprPCWk": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, FANCL, HMG20A, ZSCAN5C, SOX2, MEIS2, XBP1, PATZ1, FOXA1, SUZ12, RXRB, PBX2, MLL4, KDM3A, TFAP4, HDGF, ATF3, NFIC, ZFP64, RUNX3, CHD7, PRDM1, ZNF207, ATF4, CBFB, MXD4, SMARCE1, PAX5, TP63, BACH2, CDX2, ZNF629, MAF, KLF5, ELF1, BCLAF1, TEAD1, KLF6, ETV1, RBM39, ZNF217, ESR1, HNF1B, TP73, RCOR2, MLL, USF2, ZFP91, CTCF, TCF12, JUN, BAF155, EP300, KLF1, MNT, SOX9, SOX5, ARID5B, DPF2, LMO1, SIX5, IRF4, ZNF674, RAD51, E2F1, ZNF528, FOXA3, ZNF175, KMT2B, GTF2F1, PDX1, TFAP2C, EED, RBPJ, GLIS1, GATAD2A, MLX, POU2F2, BRD1, MYCN, POU5F1, TOP2A, ID3, CDK7, MTA2, ZBTB17, ZBTB48, STAT1, ZNF205, GATAD1, SAP130, NBN, ARID3A, SP4, TBP, HNF4G, ERG, ZBTB21, PBX1, ZNF597, ZNF341, NFKB2, MYC, SMARCA4, RFX1, HOMEZ, RAD21, RXRA, NKX2-1, PROX1, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, NFE2, MIER3, NR2F6, HNRNPH1, NR3C1, CEBPB, ESRRA, HNRNPL, STAT5B, KMT2A, CREB1, TBL1XR1, GRHL2, FEZF1, GABPB1, ZHX2, SPI1, MIXL1, TFE3, IRF1, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, FLI1, HCFC1, ZGPAT, DRAP1, SMARCA5, RELB, NFIL3, NCOA2, NFYB, ETV5, RUNX1, THAP11, CIITA, BCL6, SMC1A, CEBPA, NKX2-2, ZNF335, ZFX, SIN3A, SOX13, AFF4, SMAD3, TET2, CBX8, ERG3, SP5, TRIM22, SMARCC1, MEF2A, HDAC6, CREBBP, ZBTB2, ZNF35, NOTCH1, RARA, NFYC, RUNX2, IRF2, OSR2, ARNT, PBX4, BACH1, ATF2, PRDM9, ZNF518A, ZNF48, SMAD4, FOXM1, ETV6, MAFB, CDK8, HMGXB4, MED1, TEAD3, PML, TERF1, MYB, SCRT2, PIAS1, SMAD1, NR1H2, STAT5A, USF1, SP1, BCL11A, NIPBL, HNF4A, NR4A1, IKZF5, REST, ATF7, ASH2L, PHIP, BCOR, FOXP1, TCF3, AATF, SMC3, NCOR2, STAG1, MLLT1, NFATC3, MEF2B, PPARG, FOXA2, MTA3, CREM, EBF1, SS18, E2F8, NFATC1, ZNF692, ZSCAN16, GTF2B, ZBED1, WT1, FOXF1, ZNF600, MIER2, MEF2C, TCF7, MEIS1, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, SP140, ZIC2, HIF1A, SKIL, ZFP36, TCF4, GATA3, ZNF519, BATF, ZNF311, TAL1, MAX, NRIP1, GATA1, ZNF143, TLE3, KLF4, CEBPG, BCL11B, NCOA3, NR2F2, ZNF592, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, ZBTB6, MED, ZNF334, NFKB1, PHOX2B, BRD2, ELF3, KAT8, PHF5A, TBX21, BHLHE40, AR, NFKBIZ, TAF1, ZNF579, ZBTB40, RXR, ARID4B, PAX3-FOXO1, EGLN2, RB1, HSF1, RNF2, IKZF2, BRD4, JUND, ZBTB26, SCRT1, NCOR1, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): UMODL1,TRPM2,HSF2BP,SLC37A1,PFKL,ABCG1,DNMT3L,UBASH3A,CFAP410

Function elements

Human SNPs: .

Number of somatic mutations (coding): 18

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160190, ENSG00000160207, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185,

eachgene

Deatailed information for cohesin site CDBP00420386