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Basic information

CohesinDB ID: CDBP00420392

Locus: chr21-42542597-42549588

Data sourse: GSE206145-GSE177045, GSE143937, ENCSR000EAC, GSE67783, GSE86191, GSE98367, GSE111913, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE25021, GSE50893, GSE73207

Cell type: MCF-7, GM12892, RPE, Fibroblast, HCT-116, GM2610, TF-1, GM12878, RT-112, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 37%, "5_TxWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, HDGF, THAP1, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, PITX3, HDAC8, ZNF561, E4F1, PAX8, E2F4, ZNF410, GATAD2A, ZNF263, POU5F1, CTBP1, ERF, DUX4, STAT1, ZNF563, ERG, ZNF597, SMARCA4, DNMT1, FOXK2, ZNF197, RCOR1, CD74, DACH1, NFRKB, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, MXI1, DRAP1, RELB, EP400, RUNX1, HDAC1, NKX2-2, CEBPA, CRY1, TET2, ZNF654, TRIM22, SMARCC1, ZBTB2, ATF2, FOXM1, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, ZNF331, NR1H2, C11orf30, STAT5A, ARID2, AFF1, MBD2, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, ZFP36, TCF4, BATF, SPIB, PLAG1, BCL11B, ZNF544, ZBTB6, EGR2, RXR, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, XBP1, PBX2, ATF3, RUNX3, CBFB, DPF1, ZSCAN4, TP63, MITF, BACH2, JMJD1C, ELF1, RBM39, KLF10, ZBTB49, CTCF, JUN, MNT, LMO1, DPF2, IRF4, ZNF423, DDX20, PDX1, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, NONO, SRF, NBN, PHB2, ONECUT1, RXRA, BATF3, NKX3-1, PRDM14, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, ARHGAP35, GRHL2, EBF3, SMARCA5, CC2D1A, LDB1, AFF4, ZNF770, ZMIZ1, ZNF18, ARNT, BACH1, NFIB, ZEB2, HMBOX1, PBX3, NCAPH2, ETV6, MAFB, HMGXB4, TEAD3, DIDO1, USF1, BCL11A, SP1, ATF7, ASH2L, PRDM6, SMC3, STAG1, MLLT1, STAG2, TRP47, MTA3, EBF1, MAFF, ESR2, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, ZNF143, MTA1, CBX2, TP53, ZNF334, NFKB1, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, IRF9, ZNF468, PGR, UBTF, TFAP4, BMI1, CHD7, ATF4, ZNF189, SMARCE1, NFE2L2, ZNF217, ESR1, SAP30, SND1, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, CDK9-HEXIM1, ZSCAN5D, ZNF778, KDM4C, ASH1L, ZSCAN5A, ERG2, SP4, TBP, OGG1, SMARCC2, ETS1, MYC, ARID1B, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, PHF8, SPI1, HDAC2, INTS13, GATAD2B, ZNF490, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, CREBBP, ZNF384, ZNF35, TAF15, CBFA2T3, CDK8, ZEB1, NCOA1, SREBF2, MAFK, HNF4A, NR4A1, REST, ARID1A, BCOR, FOXP1, AATF, NCOR2, ZNF34, HDAC6, GTF2B, ZNF574, ZNF318, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, T, AR, PAX3-FOXO1, ZNF324, HEXIM1, AHR, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, MECOM, ZNF736, HDAC3, KLF5, BCLAF1, TRIM28, ETV1, USF2, TCF12, EP300, BAF155, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, ZNF175, EHMT2, EED, CHD8, MYCN, RUNX1T1, ID3, HINFP, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF667, FEZF1, HES1, ZNF664, IRF1, SREBF1, MRTFB, ATF1, SMC1A, MAFG, SIRT6, ZFX, SMAD3, CBX8, TWIST1, NSD2, IRF2, NOTCH1, BRD9, RUNX2, ZSCAN30, OSR2, ZNF184, NRF1, NR2C1, FOS, CHD1, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, ZBED1, FOXF1, ZBTB33, HOXB13, ZNF589, YY1, SP140, HIF1A, ZNF740, ZNF449, GATA1, HAND2, TLE3, NCOA3, NR2F2, ZNF687, BHLHE40, PTRF, TAF1, ZBTB40, ZBTB42, MYNN, MAZ, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): PFKL,CFAP410,UBASH3A,UMODL1,DNMT3L,SLC37A1,HSF2BP,TRPM2,ABCG1

Function elements

Human SNPs: Educational_attainment_(MTAG)

Number of somatic mutations (coding): 184

Number of somatic mutations (non-coding): 38

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160190, ENSG00000160207, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185,

eachgene

Deatailed information for cohesin site CDBP00420392