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Basic information

CohesinDB ID: CDBP00420393

Locus: chr21-42550666-42551166

Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE72082, ENCSR703TNG, GSE115602

Cell type: MCF-7

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.989

Subunit: Mau2,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 62%, "15_Quies": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, NANOG, KLF13, PGR, FOXA2, NKX2-2, POU5F1, ZNF316, SOX2, ERF, ZNF317, FOXA1, NBN, HOXB13, ERG, YY1, RELA, CREBBP, ZNF384, ASCL1, MYC, SMARCA4, GR, CHD7, RAD21, ARNT, PBX4, HIF1A, GATA3, GABPA, TAL1, STAT3, MAFB, NKX3-1, ZNF143, NRIP1, MAX, CHD1, SMARCE1, VDR, TLE3, NR3C1, ESRRA, CEBPB, NR2F2, ELF1, TEAD1, CREB1, PIAS1, ETV1, KDM5B, ZNF217, ESR1, TP53, GRHL2, TRPS1, CTCF, TCF12, BAF155, ARRB1, SP1, MNT, AR, GATA6, ZNF257, GATA2, E2F6, EGLN2, ASH2L, RNF2, BRD4, FOXP1, PDX1, AHR

Target gene symbol (double-evidenced CRMs): UMODL1,UBASH3A,RSPH1,PKNOX1,PDE9A,SLC37A1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160199,

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Deatailed information for cohesin site CDBP00420393