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Basic information

CohesinDB ID: CDBP00420395

Locus: chr21-42553370-42553876

Data sourse: ENCSR000BLD, GSE98367, GSE116868, GSE111913, ENCSR404BPV, GSE101921, ENCSR000ECE, GSE50893

Cell type: GM2630, H1-hESC, Macrophage, MB157, GM2610, Neurons-H1, HCAEC, GM2588, GM12890, GM2255, RT-112, GM19099

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 62%, "15_Quies": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, NCOA2, PGR, CBX1, SMC1A, ZSCAN5D, NKX2-2, ZSCAN5C, TOP2A, SS18, ZFX, MYCN, XBP1, ZNF316, ZBTB48, WT1, TBL1X, FOXA1, TET2, ZBTB33, SUZ12, PBX2, KDM1A, ERG, YY1, HDGF, ZNF384, TAF15, ATF3, MYC, ETS1, SMARCA4, RAD21, SP140, NFIB, ARNT, HIF1A, RXRA, GATA3, SMC3, GABPA, MGA, MAX, MAFB, NKX3-1, GATA1, ZNF143, RCOR1, NFE2, MED1, PLAG1, CEBPB, ZEB1, NCOA3, RBM39, ZMYM3, NR2F1, ESR1, MAFG, L3MBTL2, C11orf30, ZFP91, CTCF, BCL11A, BAF155, AR, ZBTB40, E2F6, RBM25, MXD3, CREB3, HSF1, RNF2, BRD4, SMARCA5, BCOR, JUND, E2F1, MAZ, SMC1, TEAD4, ZNF24, STAG1, AHR

Target gene symbol (double-evidenced CRMs): UBASH3A,ABCG1,PKNOX1,UMODL1,PDE9A,RSPH1,SLC37A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160199,

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Deatailed information for cohesin site CDBP00420395