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Basic information

CohesinDB ID: CDBP00420402

Locus: chr21-42571820-42572304

Data sourse: GSE206145, GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC, RPE

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 37%, "5_TxWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, ZSCAN5C, SOX2, MEIS2, XBP1, FOXA1, HLF, SUZ12, RXRB, PBX2, ZFHX2, HDGF, ATF3, NFIC, BMI1, THAP1, CTCFL, RUNX3, CHD7, CBFB, MXD4, PAX5, TP63, MITF, HDAC3, BACH2, JMJD1C, KLF5, TEAD1, TRIM28, BCLAF1, ELF1, RBM39, KLF6, ETV1, LMO2, ESR1, RCOR2, ZNF573, ZNF283, SNAI2, USF2, CTCF, TCF12, JUN, EP300, BAF155, E4F1, LMO1, MNT, SOX5, DPF2, PAX8, E2F6, DMAP1, IRF4, TEAD4, FOXA3, GATAD2A, PDX1, RBPJ, EED, MLX, GLIS1, GTF2F1, TFAP2C, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, TOP2A, POU5F1, ID3, CTBP1, MTA2, ERF, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ZNF563, ERG2, HNF4G, ERG, PBX1, ASCL1, OGG1, ETS1, MYC, SMARCA4, RFX1, HOMEZ, RAD21, TOP1, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, MIER3, DNMT3B, TERF2, RCOR1, NR2F6, NFE2, NR3C1, CEBPB, ZNF750, ZNF667, STAT5B, ESRRA, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, GABPB1, ZHX2, SPI1, MIXL1, KLF17, ZNF257, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, ZSCAN29, DRAP1, ZGPAT, SMARCA5, ZNF490, RELB, NFIL3, ZIM3, ATF1, PTBP1, ETV5, RUNX1, THAP11, CTNNB1, BCL6, MAFG, SMC1A, NKX2-2, SIRT6, CRY1, CEBPA, ZFX, HDAC1, SOX13, SIN3A, POU4F2, TET2, ZNF770, ERG3, SP5, SMARCC1, TWIST1, PRDM10, MEF2A, CREBBP, RARA, NOTCH1, ZBTB2, ZNF384, ARNT, NFIB, SOX11, BACH1, NRF1, ZNF48, PRDM9, SMAD4, ATF2, ETV6, PBX3, FOXM1, MAFB, HMGXB4, FOS, CHD1, SMARCB1, MED1, TEAD3, TERF1, ZEB1, MYB, SCRT2, PIAS1, KDM6B, CEBPD, ZNF3, KLF9, ZNF41, L3MBTL2, ZNF22, MAFK, SP1, BCL11A, USF1, HNF4A, TFAP2A, IKZF5, REST, ZBTB7A, ATF7, ASH2L, HNRNPLL, TCF3, BCOR, FOXP1, AATF, SMC3, NCOR2, MLLT1, STAG1, ETV4, NFATC3, PAX7, TRP47, CBFA2T2, MEF2B, ZNF316, FOXA2, PPARG, EBF1, CREM, SS18, MTA3, MIER2, ZNF600, GTF2B, WT1, MAFF, FOXF1, ZBTB33, CDK9, ZNF580, BCL3, HOXB13, KDM1A, YY1, RELA, FOXO3, TARDBP, JUNB, BRG1, SP140, ZIC2, HIF1A, ZFP36, GATA3, BATF, MGA, TAL1, MAX, MAF1, NRIP1, ZNF143, GATA1, KLF15, HAND2, PLAG1, CEBPG, BCL11B, KLF4, GFI1B, NR2F2, NCOA3, NR2F1, KDM5B, ZNF687, TP53, PKNOX1, MED, ZNF334, NFKB1, EGR2, ELF3, KAT8, TBX21, BHLHE40, AR, ARID4B, ZBTB40, RXR, EGR1, RB1, HEXIM1, HSF1, RNF2, IKZF2, BRD4, ZBTB26, JUND, NCOR1, SCRT1, MAZ, CLOCK, AHR

Target gene symbol (double-evidenced CRMs): UMODL1,SLC37A1,RSPH1,UBASH3A,PDE9A,PKNOX1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160199,

eachgene

Deatailed information for cohesin site CDBP00420402