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Basic information

CohesinDB ID: CDBP00420404

Locus: chr21-42574597-42575565

Data sourse: GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE25021, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, ENCSR000BKV, GSE115250, GSE86191, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE130135, ENCSR703TNG, GSE116344, GSE145327, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000EHX, ENCSR635OSG, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893

Cell type: RH4, Liver, TC-32, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, IMR-90, K-562, DKO, GM12891, SK-N-SH, GM19239, CNCCs-H9ESC, RT-112, MCF-7, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, TC-71

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 20% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.733

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 34%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, SUZ12, RXRB, ZFP64, CTCFL, TEAD1, TRIM28, KLF6, NFE2L2, ESR1, CTCF, KLF1, SOX5, SOX6, SMC1, TEAD4, FOXA3, GATAD2A, GTF2F1, RBPJ, TOP2A, ID3, CTBP1, SRF, SAP130, DDX5, MYC, SMARCA4, RAD21, XRCC5, ZNF614, CEBPB, CREB1, GABPB1, MIXL1, TFE3, ZNF644, DRAP1, MXI1, NFIL3, ATF1, ETV5, THAP11, CBX1, SMC1A, CEBPA, CRY1, ZFX, ZBTB2, ZNF384, OSR2, ZNF48, PRDM9, SMAD4, ATF2, FOS, HMGXB4, TEAD3, MYB, SMAD1, L3MBTL2, IKZF5, REST, SMC3, STAG1, STAG2, FOXA2, SS18, MAFF, WT1, ZNF580, ZKSCAN1, KDM1A, ZFP36, MAX, CEBPG, ZNF141, GFI1B, NEUROG2, ELF3, PHF5A, ARID4B, AR, RB1, ZBTB26, RNF2

Target gene symbol (double-evidenced CRMs): SLC37A1,HSF2BP,WDR4,UBASH3A,ABCG1,PDE9A,PKNOX1,UMODL1,U2AF1,RSPH1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 28

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160199, ENSG00000160201, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420404