- Basic information
- CohesinDB ID: CDBP00420406
- Locus: chr21-42578056-42578346
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Data sourse: GSE206145-NatGen2015, GSE111913, GSE67783, GSE86191
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Cell type: RT-112, Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"5_TxWk": 37%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, FOSL1, FOXA1, SUZ12, ATF3, BMI1, ZFP64, ZBTB5, CHD7, RUNX3, CTCFL, CBFB, PAX5, TP63, MAF, ELF1, TRIM28, SAP30, ESR1, MLL, TP73, OCA2, CTCF, BAF155, MNT, PAX8, E2F6, ZNF528, TEAD4, EED, GLIS1, POU2F2, CHD8, MYCN, ZNF263, TOP2A, RUNX1T1, POU5F1, ZBTB48, ZSCAN5A, DUX4, STAT1, ERG, ASCL1, OGG1, MYC, SMARCA4, RFX1, TOP1, GRHL3, GABPA, STAT3, APC, PRDM14, DNMT3B, NR3C1, EZH2, BMPR1A, GRHL2, ZHX2, SPI1, GATA2, FLI1, ZNF766, RUNX1, BCL6, SMC1A, SIRT6, EZH2phosphoT487, CRY1, ZFX, SMAD3, TET2, ERG3, CBX8, SMARCC1, PRDM10, CREBBP, RARA, ZNF384, TAF15, RUNX2, CDK6, ARNT, ZEB2, CBFA2T3, CHD1, FOS, CDK8, PML, TERF1, MYB, SCRT2, NR1H2, SETDB1, BCL11A, HNF4A, REST, POU2F3, HNRNPLL, TCF3, AATF, SMC3, STAG1, TRP47, CBFA2T2, SAFB, AGO1, FOXA2, SS18, PAF1, GTF2B, WT1, MEF2C, CDK9, HOXB13, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZIC2, ZFP36, HIF1A, GATA3, TAL1, MAX, ZNF449, NRIP1, ZNF143, PLAG1, CBX2, NR2F1, KDM5B, ZNF334, T, RBM14, AR, RXR, EGLN2, HEXIM1, EGR1, HSF1, RNF2, NCOR1, BRD4, NOTCH3, MAZ, ZNF440, AHR
- Target gene symbol (double-evidenced CRMs): HSF2BP,U2AF1,UMODL1,WDR4,PDE9A,RSPH1,SLC37A1,ABCG1,PKNOX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 10
- Number of somatic mutations (non-coding): 5
- Related genes and loops
- Related gene:
ENSG00000177398,
ENSG00000160179,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
ENSG00000160193,
ENSG00000160199,
ENSG00000160201,
ENSG00000160207,
- Related loop:
chr21:42125000-42150000~~chr21:42550000-42575000,
chr21:42125000-42150000~~chr21:42575000-42600000,
chr21:42150000-42175000~~chr21:42550000-42575000,
chr21:42150000-42175000~~chr21:42575000-42600000,
chr21:42300000-42325000~~chr21:42550000-42575000,
chr21:42300000-42325000~~chr21:42575000-42600000,
chr21:42308950-42311048~~chr21:42574252-42575417,
chr21:42450000-42475000~~chr21:42550000-42575000,
chr21:42475000-42500000~~chr21:42575000-42600000,
chr21:42539061-42541105~~chr21:42574098-42575530,
chr21:42539112-42541216~~chr21:42573882-42575738,
chr21:42539124-42540976~~chr21:42574171-42575456,
chr21:42550000-42575000~~chr21:42675000-42700000,
chr21:42550000-42575000~~chr21:42800000-42825000,
chr21:42550000-42575000~~chr21:43000000-43025000,
chr21:42550000-42575000~~chr21:43175000-43200000,
chr21:42575000-42600000~~chr21:42675000-42700000,
chr21:42575000-42600000~~chr21:42700000-42725000,
chr21:42575000-42600000~~chr21:42725000-42750000,
chr21:42575000-42600000~~chr21:42750000-42775000,
chr21:42575000-42600000~~chr21:42775000-42800000,
chr21:42575000-42600000~~chr21:42800000-42825000,
chr21:42575000-42600000~~chr21:42825000-42850000,
chr21:42575000-42600000~~chr21:42850000-42875000,
chr21:42575000-42600000~~chr21:42950000-42975000,
chr21:42575000-42600000~~chr21:43000000-43025000,
chr21:42575000-42600000~~chr21:43100000-43125000,
chr21:42575000-42600000~~chr21:43175000-43200000,
chr21:42575000-42600000~~chr21:43300000-43325000,
chr21:42575000-42600000~~chr21:43575000-43600000,
chr21:42575000-42600000~~chr21:43600000-43625000,
chr21:42575000-42600000~~chr21:43625000-43650000,
chr21:6425000-6450000~~chr21:42575000-42600000,