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Basic information

CohesinDB ID: CDBP00420408

Locus: chr21-42581763-42582576

Data sourse: GSE206145, GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC, RPE

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 34%, "5_TxWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, FOSL1, FOXA1, SUZ12, ATF3, BMI1, ZFP64, ZBTB5, CHD7, RUNX3, CTCFL, CBFB, PAX5, TP63, MAF, ELF1, TRIM28, SAP30, ESR1, MLL, TP73, OCA2, CTCF, BAF155, MNT, PAX8, E2F6, ZNF528, TEAD4, EED, GLIS1, POU2F2, CHD8, MYCN, ZNF263, TOP2A, RUNX1T1, POU5F1, ZBTB48, ZSCAN5A, DUX4, STAT1, ERG, ASCL1, OGG1, MYC, SMARCA4, RFX1, TOP1, GRHL3, GABPA, STAT3, APC, PRDM14, DNMT3B, NR3C1, EZH2, BMPR1A, GRHL2, ZHX2, SPI1, GATA2, FLI1, ZNF766, RUNX1, BCL6, SMC1A, SIRT6, EZH2phosphoT487, CRY1, ZFX, SMAD3, TET2, ERG3, CBX8, SMARCC1, PRDM10, CREBBP, RARA, ZNF384, TAF15, RUNX2, CDK6, ARNT, ZEB2, CBFA2T3, CHD1, FOS, CDK8, PML, TERF1, MYB, SCRT2, NR1H2, SETDB1, BCL11A, HNF4A, REST, POU2F3, HNRNPLL, TCF3, AATF, SMC3, STAG1, TRP47, CBFA2T2, SAFB, AGO1, FOXA2, SS18, PAF1, GTF2B, WT1, MEF2C, CDK9, HOXB13, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZIC2, ZFP36, HIF1A, GATA3, TAL1, MAX, ZNF449, NRIP1, ZNF143, PLAG1, CBX2, NR2F1, KDM5B, ZNF334, T, RBM14, AR, RXR, EGLN2, HEXIM1, EGR1, HSF1, RNF2, NCOR1, BRD4, NOTCH3, MAZ, ZNF440, AHR

Target gene symbol (double-evidenced CRMs): WDR4,PKNOX1,ABCG1,PDE9A,HSF2BP,U2AF1,RSPH1,SLC37A1,UMODL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160199, ENSG00000160201, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420408