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Basic information

CohesinDB ID: CDBP00420410

Locus: chr21-42586456-42597158

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 81% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.122

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 23%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, KDM3A, THAP1, ZBTB44, TEAD1, ZNF121, LMO2, OCA2, ARID5B, SOX5, PAX8, E2F4, DEK, ZNF528, GATAD2A, JARID2, ZNF263, POU5F1, TOP2A, CTBP1, ERF, STAT1, ZNF134, SAP130, ERG, SMARCA4, RCOR1, NR2F6, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, RUNX1, CEBPA, NKX2-2, ZNF654, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, SMARCB1, PIAS1, SMAD1, EVI1, GSPT2, IKZF5, CBFA2T2, MEF2B, BRF2, SS18, NFATC1, CHD2, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, ZFP36, BATF, PLAG1, BCL11B, ELF3, ARID4B, RXR, EGLN2, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, PBX2, ATF3, THRB, RUNX3, CBFB, ZSCAN4, TP63, MITF, ZNF467, JMJD1C, ELF1, RBM39, CTCF, JUN, LMO1, MNT, RYBP, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, ZBTB17, ZBTB48, NONO, SRF, DDX5, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, NR3C1, ESRRA, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, CTNNB1, EZH2phosphoT487, SOX13, AFF4, ZNF770, ARNT, ZNF48, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, ZNF680, USF1, BCL11A, SP1, ASH2L, PRDM6, SMC3, STAG1, STAG2, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, CBX2, TP53, ZNF334, NFKB1, ZNF140, BRD2, KAT8, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, PGR, SOX2, BMI1, CHD7, ZNF444, MXD4, KLF6, NFE2L2, ESR1, SOX9, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, SP4, TBP, HNF4G, HOXC5, OGG1, MYC, NKX2-1, GABPA, IKZF1, DNMT3B, EZH2, ZNF652, SPI1, HDAC2, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, RARA, NFYC, ZNF384, ZNF35, TAF15, SMAD4, CDK8, NCOA1, SREBF2, NR4A1, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF662, ZNF574, RELA, TARDBP, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, MYOD1, AR, ZBTB16, HEXIM1, DMAP1, AHR, HMGN3, SUZ12, CTCFL, MECOM, KLF5, TRIM28, BCLAF1, ETV1, TCF12, BAF155, EP300, GATA6, RAD51, E2F1, SMC1, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, JMJD6, TFE3, SREBF1, ZGPAT, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, PCBP2, CBX8, IRF2, RUNX2, SMAD2, CDK6, FOS, CHD1, MED1, KDM6B, MYB, ZNF3, L3MBTL2, KLF16, ZBTB7A, PHIP, TCF3, FOXA2, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, MYNN, NOTCH3, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): U2AF1,UMODL1,RSPH1,PDE9A,WDR4,HSF2BP,ABCG1,PKNOX1,SLC37A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 99

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160199, ENSG00000160201, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420410