- Basic information
- CohesinDB ID: CDBP00420414
- Locus: chr21-42607142-42608454
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Data sourse: GSE138405, GSE126990, GSE206145-GSE177045, GSE115602
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Cell type: MCF-7, Hela-Kyoto
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 54%,
"14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NCOA2, POU2F2, CHD8, PGR, FOXA2, POU5F1, MYCN, TOP2A, SIN3A, ZFX, TEAD4, XBP1, CTBP1, DUX4, ZBTB48, STAT1, FOXA1, SMAD3, HNF1A, ERG, YY1, RELA, CREBBP, USP7, AHR, EZH1, NFIC, GRHL3, HIF1A, ARNT, GATA3, GABPA, STAT3, ETV6, SMARCE1, NRIP1, ZNF143, MED1, NR3C1, ESRRA, ZNF750, NCOA3, NR2F2, TRIM28, BAP1, TEAD1, CEBPB, EZH2, KDM5B, ESR1, OCA2, TP53, NCOA1, GRHL2, ZNF334, PKNOX1, CTCF, JUN, TCF12, BCL11A, E4F1, TFAP2A, MNT, AR, GATA6, BAF155, DPF2, EP300, YAP1, EGLN2, PRKDC, BRD4, ZNF528, SMC3, ZNF554, ZNF24, STAG1, TFAP2C, EED
- Target gene symbol (double-evidenced CRMs): PDE9A,RRP1B,HSF2BP,CBS,PKNOX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160191,
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160208,
- Related loop:
chr21:42600000-42625000~~chr21:42700000-42725000,
chr21:42600000-42625000~~chr21:42725000-42750000,
chr21:42600000-42625000~~chr21:42800000-42825000,
chr21:42600000-42625000~~chr21:43025000-43050000,
chr21:42600000-42625000~~chr21:43175000-43200000,
chr21:42600000-42625000~~chr21:43625000-43650000,
chr21:42600000-42625000~~chr21:43650000-43675000,