Deatailed information for cohesin site CDBP00420416

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  • Basic information
  • CohesinDB ID: CDBP00420416
  • Locus: chr21-42614071-42618253
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, GSE105028, GSE131606, GSE25021, ENCSR000EDW, GSE115602, ENCSR917QNE, GSE67783, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE116344, GSE98367, ENCSR000BLS, GSE85526, ENCSR000ECE, ENCSR000BTQ, GSE110061, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, GSE126755, ENCSR000ECS
  • Cell type: RH4, GM2610, Liver, HuCC-T1, H9-hESC, Fibroblast, HEKn, HeLa-S3, K-562, H1-hESC, Monocytes, MB157, RT-112, Macrophage, MCF-7, HCT-116, Hep-G2, Neutrophil, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 12% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.789
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 86% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 19%, "14_ReprPCWk": 19%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, KDM3A, HDGF, THAP1, ZNF429, PAX5, TEAD1, LMO2, OCA2, MED26, ARID5B, E4F1, SOX5, ZNF407, E2F4, ZNF410, ZNF528, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, CTBP1, STAT1, SAP130, ERG, EZH1, SMARCA4, RFX1, FOXK2, ZNF8, RCOR1, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, FLI1, DRAP1, ZNF785, RELB, HCFC1R1, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, ZNF707, TET2, MCM2, TRIM22, SMARCC1, ZXDC, ZBTB2, TFDP1, ATF2, SMARCB1, EVI1, IKZF5, ARID2, ZNF605, ELL2, MEF2B, ZNF207, SS18, WT1, MEF2C, NEUROD1, MCM3, ZFP36, ZNF311, MAF1, KLF4, BCL11B, IRF5, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, RUNX1-3, FOSL1, HNF1A, XBP1, PBX2, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, CDC5L, MAF, JMJD1C, ELF1, RBM39, SNAI2, CTCF, JUN, LMO1, MNT, DPF2, IRF4, PLRG1, PDX1, TFAP2C, RBPJ, YBX1, ZNF239, ZSCAN21, MTA2, ZBTB17, ZBTB48, NONO, SRF, DDX5, NBN, CHD4, PBX1, ONECUT1, TRIP13, TSHZ1, HOMEZ, RXRA, NKX3-1, MIER3, HNRNPH1, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, ARHGAP35, GRHL2, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, ZBTB24, LDB1, AFF4, ZNF747, ZNF18, ARNT, NFIB, ZNF48, ZEB2, PBX3, HMGXB4, TEAD3, ZNF670, ZNF680, U2AF1, BCL11A, SP1, TFAP2A, ATF7, CTBP2, SMC3, MLLT1, STAG1, TRP47, AGO1, MTA3, MEIS1, ZKSCAN1, BCL3, KDM1A, ZNF266, BRG1, GATA3, TAL1, NRIP1, ZNF143, CBX2, TP53, ZNF334, BRD2, KAT8, TBX21, RB1, TFIIIC, RNF2, IKZF2, BRD4, ZSCAN23, IRF9, TBX2, PGR, UBTF, BMI1, ZNF444, MXD4, SMARCE1, KLF6, MCM7, ESR1, KLF1, SOX9, TRIM24, PRKDC, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ZSCAN5A, ERG2, TBP, OGG1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, YBX3, EZH2, SPI1, HDAC2, GATAD2B, ATM, NCOA2, ZNF554, ZNF76, ETV5, BCL6, NFXL1, ERG3, RARA, CREBBP, ZNF280C, SMAD4, CDK8, ZEB1, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, TBL1X, ZNF662, RELA, TARDBP, ZNF282, MAX, ZNF592, NR2F1, KDM5B, PKNOX1, AR, ZNF445, PAX3-FOXO1, HEXIM1, AHR, MBD3, HMG20A, MEIS2, SUZ12, ZFHX2, ZBTB5, MECOM, ZNF736, TRIM28, BCLAF1, RCOR2, HNF1B, TCF12, EP300, GATA6, GLI4, SOX6, RAD51, ZNF512B, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, CDK7, ID3, GATAD1, ARID3A, MCM5, RAD21, GRHL3, XRCC5, ZNF614, ZNF639, ZNF750, TRPS1, HES1, TFE3, EHF, IRF1, ZGPAT, ZNF418, ZIM3, SMC1A, CBX1, ZNF335, ZFX, CBX8, NOTCH1, BRD9, RUNX2, GATA4, OSR2, GR, ZNF184, PBX4, NRF1, FOS, CHD1, MED1, CEBPD, MYB, SCRT2, KDM6B, PHF20, ZBTB7A, POU2F3, TCF3, NCOA4, KLF13, FOXA2, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, GATA1, CEBPG, NCOA3, NR2F2, ZNF687, ZNF837, NFKBIZ, BHLHE40, ZBTB40, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): CBS,RRP1B,PKNOX1,HSF2BP,PDE9A
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 13
  • Related genes and loops
  • Related gene: ENSG00000160191, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160208,
  • Related loop: chr21:42600000-42625000~~chr21:42700000-42725000, chr21:42600000-42625000~~chr21:42725000-42750000, chr21:42600000-42625000~~chr21:42800000-42825000, chr21:42600000-42625000~~chr21:43025000-43050000, chr21:42600000-42625000~~chr21:43175000-43200000, chr21:42600000-42625000~~chr21:43625000-43650000, chr21:42600000-42625000~~chr21:43650000-43675000,
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