- Basic information
- CohesinDB ID: CDBP00420427
- Locus: chr21-42641160-42643201
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Data sourse: ENCSR000BLD, GSE67783, GSE86191, ENCSR404BPV, ENCSR198ZYJ, GSE97394
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Cell type: H1-hESC, HCT-116, Neurons-H1, HSPC, HUES64
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SMC3,Rad21,SA1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 20%,
"7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, HLF, RXRB, ZBTB7B, TEAD1, LMO2, SOX5, PAX8, ZNF407, E2F4, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, SAP130, ZNF485, ERG, SMARCA4, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, NR2C2, HCFC1R1, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, TET2, ZNF473, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ATF2, SMARCB1, GMEB1, C11orf30, EVI1, STAT5A, IKZF5, ARID2, RBM25, ELL2, ETV4, CBFA2T2, CBX3, ZNF207, CHD2, SS18, NFATC1, ZSCAN16, WT1, JUNB, MCM3, ZNF311, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, ZNF316, FOSL1, ZNF660, ZNF621, HNF1A, XBP1, KDM4B, PBX2, THRB, ATF3, ZFP64, CBFB, TP63, ZSCAN4, MITF, ZNF467, ZNF780A, JMJD1C, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, LMO1, DPF2, RYBP, ZNF776, PLRG1, PDX1, TFAP2C, RBPJ, MLX, YBX1, MTA2, ZBTB17, ZBTB48, ZNF317, DDX5, PHB2, PBX1, ONECUT1, HOMEZ, RXRA, NKX3-1, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, ARHGAP35, GRHL2, EBF3, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, SOX13, AFF4, ARNT, NFIB, ZNF48, PRDM9, ZEB2, PBX3, MAFB, HMGXB4, TEAD3, KLF9, TBX5, USF1, BCL11A, SP1, NKX2-5, ATF7, ASH2L, CTBP2, PCGF2, SMC3, STAG1, MLLT1, TRP47, SAFB, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KDM1A, ZNF19, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, ZNF334, NFKB1, PHOX2B, PHF5A, KAT8, ARRB1, TBX21, EGR1, RNF2, BRD4, JUND, CUX1, PGR, SOX2, BMI1, CHD7, ZNF444, MXD4, KLF6, MCM7, NFE2L2, SAP30, ESR1, SND1, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZBTB1, ZSCAN5A, ERG2, TBP, HNF4G, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, SRSF3, YBX3, EZH2, ZNF652, PHF8, SPI1, HDAC2, GATAD2B, NCOA2, ETV5, SALL2, BCL6, SIN3A, ERG3, MYBL2, RARA, CREBBP, NFYC, ZNF384, ZNF35, SMAD4, CBFA2T3, CDK8, SNRNP70, ZEB1, ZMYM3, MAFK, HNF4A, ZNF799, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, HDAC6, ZNF662, RELA, TARDBP, CHAMP1, MGA, MAX, ZNF592, NR2F1, KDM5B, PKNOX1, AR, ZZZ3, DMAP1, AHR, MBD3, FOSL2, HMG20A, MEIS2, SUZ12, ZFHX2, NFIC, MECOM, HDAC3, CDX2, THRAP3, TRIM28, ETV1, RCOR2, HNF1B, TCF12, EP300, BAF155, GATA6, ZNF512B, E2F1, TEAD4, FOXA3, EHMT2, ATRX, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ASCL1, MIER1, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, FEZF1, TFE3, EHF, IRF1, ZGPAT, MRTFB, ZIM3, CBX1, SMC1A, SIRT6, ZFX, ZNF534, SMAD3, CBX8, TWIST1, PRPF4, BRD9, GATA4, ZNF184, NRF1, PBX4, NR2C1, FOS, CHD1, MED1, CEBPD, MYB, SCRT2, ZNF3, L3MBTL2, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, PAX7, SKI, FOXA2, MIER2, ZNF600, FOXF1, ZBTB33, HOXB13, YY1, ZNF148, ZNF521, BRCA1, SP140, HIF1A, OTX2, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, BHLHE40, NFKBIZ, MYNN, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): PKNOX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 9
- Related genes and loops