- Basic information
- CohesinDB ID: CDBP00420429
- Locus: chr21-42644311-42645944
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Data sourse: GSE67783, GSE72082, GSE86191, GSE111913, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT
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Cell type: Fibroblast, HCT-116, Hep-G2, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 34%,
"14_ReprPCWk": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, XBP1, PATZ1, FOXA1, SUZ12, PBX2, ZFHX2, ATF3, ZFP64, CHD7, PRDM1, ATF4, CBFB, ZNF189, DPF1, MITF, ZNF629, ZNF506, TEAD1, TRIM28, ZNF121, ETV1, ESR1, HDAC8, USF2, CTCF, JUN, EP300, MNT, SOX5, E2F6, TRIM24, RAD51, ZNF528, TEAD4, FOXA3, ZNF175, TFAP2C, GLIS1, CHD8, BRD1, ZSCAN5D, ZNF263, POU5F1, TOP2A, MYCN, KDM4C, CTBP1, ZSCAN21, ZBTB17, ZBTB48, SAP130, ERG, ZBTB21, ASCL1, OGG1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, FOXK2, STAT3, XRCC5, PRDM14, IKZF1, DNMT3B, CEBPB, ESRRA, HNRNPL, CREB1, EZH2, GRHL2, SPI1, PCBP1, GATA2, FLI1, DRAP1, NR2C2, MRTFB, ATF1, ETV5, RUNX1, BCL6, CEBPA, HDAC1, CRY1, ZNF335, ZFX, SMAD3, TET2, ERG3, ZNF770, SMARCC1, PRDM10, MEF2A, PBX4, ATF2, ZNF48, SMAD4, CBFA2T3, FOS, TEAD3, SCRT2, ZNF3, L3MBTL2, MAFK, BCL11A, USF1, REST, ZNF479, ATF7, HNRNPLL, FOXP1, AATF, SMC3, STAG1, ZNF394, TRP47, CBFA2T2, ZNF283, FOXA2, CBX3, MTA3, SS18, ZNF600, ZNF692, WT1, ESR2, MEF2C, CDK9, BCL3, ZKSCAN1, ZNF589, YY1, RELA, NEUROD1, JUNB, BRG1, SP140, ZFP36, ZIC2, HIF1A, OTX2, MGA, TAL1, MAX, NRIP1, ZNF143, GATA1, CBX2, PLAG1, CEBPG, GFI1B, NR2F2, NR2F1, KDM5B, PKNOX1, ZBTB6, ZSCAN22, EGR2, BRD2, ARID4B, BHLHE40, AR, RXR, ZNF366, TFIIIC, ZBTB26, RNF2, HSF1, JUND, BRD4, SCRT1, CLOCK, MAZ, MEF2D, ZFP42, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PKNOX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000160199,
- Related loop:
chr21:34150000-34175000~~chr21:42625000-42650000,
chr21:41200000-41225000~~chr21:42650000-42675000,
chr21:41700000-41725000~~chr21:42650000-42675000,
chr21:41750000-41775000~~chr21:42650000-42675000,
chr21:42125000-42150000~~chr21:42650000-42675000,
chr21:42625000-42650000~~chr21:42800000-42825000,
chr21:42625000-42650000~~chr21:43000000-43025000,
chr21:42625000-42650000~~chr21:43175000-43200000,
chr21:42650000-42675000~~chr21:42800000-42825000,
chr21:42650000-42675000~~chr21:43000000-43025000,
chr21:42650000-42675000~~chr21:43175000-43200000,
chr21:42650000-42675000~~chr21:43300000-43325000,
chr21:42650000-42675000~~chr21:43950000-43975000,
chr21:6425000-6450000~~chr21:42625000-42650000,