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Basic information

CohesinDB ID: CDBP00420432

Locus: chr21-42651659-42660395

Data sourse: ENCSR230ZWH, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE67783, GSE86191, GSE101921, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR054FKH, GSE83726, GSE126755, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE131577, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR000BTQ, GSE129526, ENCSR000BLY, GSE121355, GSE111537, GSE25021, GSE76893, GSE145327, GSE76815, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, SLK, CVB-hiPSC, OCI-AML-3, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, BCBL-1, K-562, DKO, H1-hESC, SNYDER, Monocytes, MB157, GBM39, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, HeLa, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 37% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.522

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 16%, "2_TssAFlnk": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, KDM3A, HDGF, THAP1, IKZF3, MORC2, PAX5, ZNF320, TEAD1, LMO2, PITX3, ZNF561, SOX5, E2F4, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, STAT1, ZNF134, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, HCFC1, MXI1, HCFC1R1, RUNX1, CEBPA, NKX2-2, ZNF707, HDAC1, TET2, SP5, SMARCC1, PRDM10, ZBTB2, SOX11, ZBTB10, SP2, SMARCB1, PIAS1, EVI1, MBD1, IKZF5, ARID2, RBM25, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, WT1, NEUROD1, MCM3, TCF4, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZNF281, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, ZNF273, TP63, ZSCAN4, ZNF467, JMJD1C, MAF, ELF1, ZNF573, RBM39, SNAI2, FUS, CTCF, TAF3, L3MBTL4, ZBTB20, MNT, RYBP, DPF2, ZNF423, PDX1, TFAP2C, RBPJ, ZNF317, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, PBX1, KDM4A, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, KMT2A, ZBTB11, CCAR2, KLF8, GRHL2, EBF3, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF18, SP3, ARNT, NFIB, ZNF48, PRDM9, ZEB2, PBX3, MAFB, ZNF10, NCAPH2, HMGXB4, TEAD3, ZXDB, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ASH2L, GLIS2, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF441, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, ZSCAN22, PHF5A, BRD2, KAT8, TBX21, EGR1, TFIIIC, IKZF2, BRD4, JUND, SPIN1, PGR, SOX2, PATZ1, RING1B, TFAP4, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, KLF1, SOX4, E2F6, TRIM24, RFX5, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, GATAD2B, ETV5, BCL6, SIN3A, ERG3, RARA, CREBBP, ZNF35, TAF15, SMAD4, CDK8, CSNK2A1, ZEB1, ZMYM3, RBM22, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, ZNF543, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, ZNF692, ZNF30, ZNF662, RELA, TARDBP, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, ZNF547, RUVBL1, MYOD1, T, AR, ZNF324, HEXIM1, DMAP1, AHR, MBD3, HMG20A, ZSCAN5C, SUZ12, RBFOX2, ZFHX2, ZNF90, NFIC, CTCFL, PRDM1, MECOM, ZNF736, HDAC3, KLF5, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, PRDM4, E2F1, SMC1, TEAD4, FOXA3, EED, CHD8, BRD1, MYCN, CDK7, ID3, GATAD1, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, TFE3, HBP1, ZNF664, ZGPAT, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, ZNF335, SMAD3, CBX8, TWIST1, PRPF4, NOTCH1, RUNX2, SMAD2, OSR2, ZNF184, NRF1, PBX4, FOS, CHD1, MED1, CEBPD, MYB, SCRT2, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, FOXF1, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, BHLHE40, NFKBIZ, TAF1, ZBTB42, MYNN, MAZ

Target gene symbol (double-evidenced CRMs): BACE2,WDR4,AGPAT3,UMODL1,PKNOX1,PDE9A,RIPK4

Function elements

Human SNPs: Ischemic_stroke_in_hypertension

Number of somatic mutations (coding): 429

Number of somatic mutations (non-coding): 36

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183421, ENSG00000177398, ENSG00000160191, ENSG00000160193, ENSG00000160199, ENSG00000160216,

eachgene

Deatailed information for cohesin site CDBP00420432