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Basic information

CohesinDB ID: CDBP00420437

Locus: chr21-42676262-42677139

Data sourse: GSE116344, ENCSR153HNT, GSE86191

Cell type: K-562, RH4, HCT-116

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 41%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF195, ZNF675, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, LMO2, OCA2, ZNF23, PITX3, ZNF561, E4F1, ARID5B, ZNF157, SOX5, PAX8, ZNF407, ZNF211, DEK, ZNF410, ZNF528, KMT2B, GATAD2A, NANOG, POU5F1, ZNF263, TOP2A, CTBP1, ERF, DUX4, STAT1, ZNF488, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, ZNF785, DRAP1, MXI1, HCFC1R1, RUNX1, CEBPA, HDAC1, NKX2-2, ZNF707, CRY1, REPIN1, ZNF658, TET2, ZNF473, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, SOX11, ZBTB10, SNIP1, ATF2, FOXM1, SP2, SMARCB1, PIAS1, SMAD1, EVI1, STAT5A, GSPT2, ARID2, IKZF5, OVOL3, RBM25, ZNF605, AFF1, ELL2, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, NFATC1, PAF1, ZSCAN16, WT1, NEUROD1, JUNB, MCM3, TCF4, ZNF311, MAF1, ZSCAN26, PLAG1, KLF4, BCL11B, ZFP69B, ZNF544, IRF5, ZBTB6, MED, BCL6B, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, ZNF621, XBP1, HNF1A, PBX2, ATF3, ZFP64, RUNX3, CBFB, ZSCAN4, TP63, BACH2, CDC5L, ZNF467, MAF, JMJD1C, MYOG, ELF1, RBM39, KLF10, ZNF624, ZIK1, CTCF, JUN, MNT, ZBTB20, LMO1, DPF2, RYBP, IRF4, ZNF423, ZNF776, ZNF280A, PDX1, TFAP2C, RBPJ, PLRG1, YBX1, MLX, ZNF239, MTA2, ZSCAN21, ZBTB17, ZBTB48, ZNF317, NONO, SRF, DDX5, NBN, PHB2, PBX1, ONECUT1, ZNF2, TSHZ1, HOMEZ, RXRA, BATF3, NKX3-1, PRDM14, MIER3, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, ARHGAP35, ZNF292, EBF3, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, ZBTB24, LDB1, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF747, ZNF770, ZNF513, ZNF18, SP3, NFIB, ARNT, DAXX, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, TEAD3, ZNF670, ZXDB, ZNF680, KLF9, TBX5, USF1, SP1, BCL11A, ATF7, ASH2L, GLIS2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, KLF7, ZNF441, ZNF266, BRG1, ISL1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, CBX2, TP53, ZNF645, ZNF334, NFKB1, ZSCAN22, ZNF140, PHOX2B, BRD2, KAT8, TBX21, ZFP41, EGR1, RB1, TFIIIC, RNF2, BRD4, PRDM2, JUND, ZSCAN23, IRF9, TBX2, PGR, SOX2, PATZ1, UBTF, TFAP4, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, ESR1, TP73, ZNF524, KLF1, SOX4, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZBTB1, ASH1L, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, ZNF652, SPI1, ZNF786, PCBP1, HDAC2, GATAD2B, ZNF490, NCOA2, ZNF76, ZNF554, SALL2, ETV5, BCL6, SIN3A, ERG3, NFXL1, CREBBP, ZNF35, RARA, ZNF384, ZNF169, NFYC, TAF15, ZNF280C, SMAD4, CBFA2T3, CDK8, ZEB1, SPDEF, ZMYM3, NCOA1, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, ZNF34, PPARG, TBL1X, ZNF692, GTF2B, ZNF662, ZNF574, TCF7, YY2, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, GFI1B, BAP1, ZNF791, NR2F1, KDM5B, TCF7L2, PKNOX1, MYOD1, T, AR, ZNF445, ZBTB16, YAP1, ZNF324, HEXIM1, AHR, FOSL2, ZNF391, HMG20A, LCORL, ZSCAN5C, SUZ12, RBFOX2, ZFHX2, LYL1, ZNF274, INSM2, NFIC, ZNF90, ZBTB5, CTCFL, PRDM1, KLF14, MECOM, HDAC3, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, TEAD4, FOXA3, ZNF175, EHMT2, ATRX, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, AEBP2, ZNF585B, ASCL1, ZNF341, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, FEZF1, TRPS1, HES1, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, ZIM3, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, TWIST1, ZNF701, PRPF4, NOTCH1, RUNX2, SMAD2, GATA4, OSR2, ZNF184, CDK6, NRF1, PBX4, CHD1, FOS, SUPT5H, MED1, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, POU2F3, PHIP, TCF3, SALL1, PAX7, SKI, ZNF283, NCOA4, KLF13, FOXA2, ZNF600, MIER2, ZNF493, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF837, ZNF213, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): UMODL1,PDE9A,ABCG1,C2CD2,SLC37A1,PKNOX1,CBS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 39

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191, ENSG00000160199, ENSG00000160200,

eachgene

Deatailed information for cohesin site CDBP00420437