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Basic information

CohesinDB ID: CDBP00420440

Locus: chr21-42682647-42686811

Data sourse: GSE67783, GSE86191, GSE138405, GSE116868, GSE111913, GSE105028, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, GSE68388, GSE83726, GSE103477, GSE111537, GSE126990, GSE108869

Cell type: RPE, Hela-Kyoto, Fibroblast, HCT-116, MB157, RH4, THP-1, HeLa-S3, RT-112, K-562, OCI-AML-3, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.844

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 26%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF394, CBX2, PRDM1, FOXA1, HOXB13, ERG

Target gene symbol (double-evidenced CRMs): C2CD2,CBS,PDE9A,ABCG1,SLC37A1,UMODL1,PKNOX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 624

Number of somatic mutations (non-coding): 29

Related genes and loops

Related gene: ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191, ENSG00000160199, ENSG00000160200,

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Deatailed information for cohesin site CDBP00420440