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Basic information

CohesinDB ID: CDBP00420443

Locus: chr21-42692085-42693894

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 37%, "4_Tx": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, LCORL, ZNF621, XBP1, FOXA1, SUZ12, ZBTB7B, HDGF, ATF3, BMI1, CTCFL, ZBTB5, ZNF444, ZNF320, TRIM28, LMO2, ESR1, OCA2, ZNF571, CTCF, KLF1, E4F1, DPF2, E2F6, ZNF512B, ZNF776, ZNF175, EHMT2, YBX1, POU2F2, BRD1, MYCN, ZNF263, POU5F1, ID3, TOP2A, CTBP1, ZBTB1, ZSCAN21, ZBTB48, ZSCAN5A, STAT1, MTA2, NONO, SRF, ZNF317, DDX5, ARID3A, PHB2, ERG, OGG1, MYC, MCM5, SMARCA4, RFX1, RAD21, GRHL3, RXRA, FOXK2, STAT3, XRCC5, ZNF8, IKZF1, RCOR1, DNMT3B, HNRNPH1, NR2F6, ZNF639, CREB1, EZH2, ARHGAP35, GABPB1, HES1, HDAC2, GATAD2B, MXD3, FLI1, ATM, NFIL3, ETV5, SALL2, RUNX1, BCL6, SMC1A, CEBPA, SIRT6, HDAC1, ZFX, ZNF747, SMAD3, TET2, ERG3, TBX3, SP5, TRIM22, ZNF18, SMARCC1, ZBTB2, CREBBP, RARA, TAF15, ZNF184, NFIB, ARNT, ZNF48, ZEB2, NCAPH2, FOS, CDK8, CHD1, ZEB1, TEAD3, KDM6B, SCRT2, ZNF680, KLF9, L3MBTL2, RBM22, BCL11A, REST, ZBTB7A, HNRNPLL, TCF3, BCOR, FOXP1, AATF, SMC3, STAG1, MLLT1, TRP47, CBFA2T2, KLF13, FOXA2, AGO1, EBF1, MTA3, SS18, PAF1, ZNF207, WT1, ZNF662, ZBTB33, CDK9, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, ZNF148, BRG1, ZNF521, MCM3, SP140, HIF1A, ZNF311, MAX, ZNF143, AGO2, GATA1, MTA1, CBX2, PLAG1, ZNF592, NCOA3, ZNF544, NR2F1, ZNF791, KDM5B, ZNF687, ZBTB6, ZNF334, BCL6B, EGR2, ARID4B, AR, RXR, HEXIM1, TFIIIC, HSF1, RNF2, SCRT1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): PKNOX1,PDE9A,SLC37A1,C2CD2,UMODL1,CBS,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 117

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191, ENSG00000160199, ENSG00000160200,

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Deatailed information for cohesin site CDBP00420443