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Basic information

CohesinDB ID: CDBP00420444

Locus: chr21-42694195-42694540

Data sourse: GSE67783, GSE86191

Cell type: HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 38%, "15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, FOXA1, ZFHX2, ZNF90, INSM2, ATF3, TP63, ELF1, TRIM28, ESR1, CTCF, JUN, BAF155, E4F1, KLF1, ZNF528, TEAD4, TFAP2C, BRD1, ZSCAN5D, MYCN, POU5F1, ZSCAN21, ZBTB48, ZSCAN5A, DUX4, ERG2, ERG, HOXC5, ASCL1, MYC, ARID1B, GRHL3, NKX2-1, STAT3, XRCC5, NKX3-1, RCOR1, DNMT3B, HNRNPH1, NFE2, CREB1, EZH2, SPI1, GATA2, FLI1, MRTFB, ZNF554, RUNX1, BCL6, CEBPA, LDB1, CRY1, ZFX, TET2, ZNF770, ERG3, ZNF513, ZNF549, CREBBP, ZNF384, TAF15, OSR2, ZNF184, ARNT, SOX11, ZNF48, PRDM9, ZEB2, PBX3, CBFA2T3, FOS, CHD1, CEBPD, MYB, RBM22, BCL11A, REST, HNRNPLL, SMC3, STAG1, ZNF394, TRP47, CBFA2T2, PAF1, ZNF600, WT1, ZNF30, YY1, RELA, JUNB, ZNF148, SP140, HIF1A, OTX2, TAL1, MAX, GATA1, AGO2, PLAG1, NR2F1, KDM5B, ZBTB6, EGR2, AR, ZBTB42, ZBTB26, HSF1, RNF2, JUND, BRD4, MAZ, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): SLC37A1,PDE9A,ABCG1,PKNOX1,C2CD2,CBS,UMODL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 78

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191, ENSG00000160199, ENSG00000160200,

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Deatailed information for cohesin site CDBP00420444