- Basic information
- CohesinDB ID: CDBP00420450
- Locus: chr21-42705334-42706618
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Data sourse: ENCSR000BLD, GSE67783, ENCSR000BKV, GSE72082, GSE138405, GSE86191, GSE129526, GSE111913, ENCSR000BLY, GSE25021, ENCSR000BLS, GSE105028, GSE76893, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, RH4, SNYDER, GM12891, RT-112, HSPC, K-562, GM19239, SK-N-SH, GM18951, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.800
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 34%,
"15_Quies": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, HMG20A, XBP1, FOXA1, SUZ12, PBX2, RXRB, KDM3A, TFAP4, ATF3, THRB, CHD7, ZNF444, PAX5, TP63, MITF, ZNF736, TEAD1, TRIM28, KLF6, RBM39, LMO2, RCOR2, OCA2, ESR1, CTCF, TCF12, JUN, E4F1, SOX5, DPF2, E2F6, TRIM24, ZNF280A, TEAD4, FOXA3, ZNF175, GTF2F1, GATAD2A, RBPJ, EED, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, RUNX1T1, POU5F1, MTA2, ZNF317, DUX4, ZSCAN5A, STAT1, ZBTB48, SRF, GATAD1, SAP130, NBN, ERG, PBX1, OGG1, MYC, SMARCA4, ARID1B, RAD21, HOMEZ, GRHL3, RXRA, STAT3, ZNF614, IKZF1, DNMT3B, HNRNPH1, NR2F6, ESRRA, CEBPB, KMT2A, CREB1, EZH2, GABPB1, TFE3, MIXL1, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, FLI1, DRAP1, ZGPAT, RELB, HCFC1R1, NFIL3, ATF1, PTBP1, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, LDB1, SOX13, ZFX, TET2, CBX8, ZBTB2, ZNF384, RARA, PRPF4, CDK6, ARNT, ATF2, PRDM9, ZNF48, SMAD4, CBFA2T3, FOXM1, CHD1, FOS, HMGXB4, TEAD3, CEBPD, KDM6B, ZNF680, MYB, NCOA1, SETDB1, TBX5, RBM22, BCL11A, SP1, HNF4A, IKZF5, NKX2-5, ZNF479, ATF7, HNRNPLL, TCF3, FOXP1, AATF, SMC3, STAG1, NFATC3, SKI, TRP47, CBFA2T2, PPARG, AGO1, FOXA2, MIER2, ZNF600, WT1, HOXB13, ZNF580, KDM1A, YY1, RELA, TARDBP, SP140, ZIC2, ZFP36, TAL1, MAX, GATA1, AGO2, ZNF143, CBX2, CEBPG, NCOA3, NR2F2, ZNF791, NR2F1, TP53, PKNOX1, ZNF334, EGR2, PHF5A, ELF3, KAT8, ARID4B, AR, RXR, ZBTB42, HEXIM1, HSF1, RNF2, NCOR1, JUND, BRD4, ZBTB26, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): SLC37A1,PDE9A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 156
- Number of somatic mutations (non-coding): 12
- Related genes and loops