- Basic information
- CohesinDB ID: CDBP00420453
- Locus: chr21-42711194-42712193
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Data sourse: ENCSR167MTG, ENCSR000EEG, ENCSR338DUC, ENCSR230ZWH, GSE67783, GSE72082, GSE76893, ENCSR000BLS, ENCSR054FKH, ENCSR000EDW, ENCSR917QNE
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Cell type: Liver, HSPC, Hep-G2
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SMC3,Rad21,SA1,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 45%,
"5_TxWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, LCORL, SOX2, XBP1, HNF1A, FOXA1, HLF, RXRB, KDM3A, TFAP4, SIN3B, THRB, NFIC, ATF3, ZFP64, ZNF362, CHD7, PRDM1, MXD4, HDAC3, TEAD1, ELF1, KLF6, ETV1, RCOR2, ESR1, JUN, CTCF, EP300, KLF1, L3MBTL4, BAF155, SOX5, ZNF528, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, MLX, CHD8, TOP2A, ZBTB48, DUX4, SRF, GATAD1, SAP130, ARID3A, HNF4G, ERG, ZNF341, ETS1, ONECUT1, HOMEZ, RAD21, RXRA, NKX2-1, FOXK2, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, MIER3, DNMT3B, NR2F6, CEBPB, HNRNPL, CREB1, CCAR2, TBL1XR1, GRHL2, ZNF652, EBF3, GABPB1, ZHX2, SPI1, MIXL1, HBP1, TFE3, HDAC2, GATA2, ZNF644, MXD3, DRAP1, ZGPAT, NFIL3, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, NKX2-2, SIN3A, ZFX, SOX13, POU4F2, ZNF770, CBX8, TBX3, SP5, SMARCC1, MYBL2, RARA, ZNF384, NFYC, CREBBP, RUNX2, CDK6, GATA4, ARNT, ATF2, ZNF48, SMAD4, FOS, HMGXB4, TGIF2, MED1, TEAD3, CEBPD, ZMYM3, PIAS1, ZNF3, MBD1, ZNF22, RBM22, SP1, HNF4A, IKZF5, REST, ATF7, ASH2L, FOXP1, ETV4, SKI, PPARG, FOXA2, CREM, ZNF600, MIER2, GTF2B, WT1, ZBTB33, TCF7, CDK9, ZNF580, HOXB13, FOXO3, KDM1A, YY1, RELA, AHR, KAT2B, SP140, GATA3, MAX, CBX2, CEBPG, NR2F2, MYOD1, PHF5A, ELF3, KAT8, ARID4B, NFKBIZ, AR, EGR1, ZBTB26, RNF2, JUND, BRD4, CUX1, SMAD4.1D12, DMAP1, FOSL2
- Target gene symbol (double-evidenced CRMs): SLC37A1,PDE9A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 13
- Number of somatic mutations (non-coding): 0
- Related genes and loops