Deatailed information for cohesin site CDBP00420456

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  • Basic information
  • CohesinDB ID: CDBP00420456
  • Locus: chr21-42719553-42721821
  • Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE105028, GSE111537, GSE131606, ENCSR917QNE, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE116344, ENCSR338DUC, GSE206145, ENCSR000ECE, GSE129526, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990
  • Cell type: H1-hESC, Fibroblast, HCT-116, Hela-Kyoto, HEK293T, Hep-G2, RH4, HCAEC, K-562, Liver, OCI-AML-3, HSPC, HuCC-T1, H9-hESC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 6% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.844
  • Subunit: SA1,Rad21,SA2,SMC1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 86% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 28%, "7_Enh": 26%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZNF660, ZSCAN5C, PATZ1, FOXA1, HLF, SUZ12, RXRB, ZNF596, ATF3, INSM2, THRB, ZNF362, CTCFL, CHD7, ZNF189, CDX2, ZNF629, JMJD1C, TEAD1, TRIM28, KLF6, NFE2L2, KLF10, RCOR2, ESR1, HNF1B, CTCF, JUN, BAF155, SOX5, TEAD4, FOXA3, GATAD2A, PDX1, RBPJ, GLIS1, MYCN, ZSCAN21, ZBTB17, ZBTB48, ERF, SRF, GATAD1, DDX5, SAP130, TBP, HNF4G, HOXC5, ZBTB21, ERG, ASCL1, SMARCC2, ONECUT1, MYC, SMARCA4, ZNF2, TSHZ1, RAD21, LHX2, HOMEZ, GRHL3, RXRA, PROX1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, RCOR1, MIER3, ZNF639, NR2F6, VDR, NR3C1, CEBPB, ESRRA, CREB1, CCAR2, EZH2, KLF8, EBF3, SPI1, IRF1, KLF17, GATA2, ZNF644, SIX2, FLI1, DRAP1, ZGPAT, NFIL3, ZNF76, ETV5, RUNX1, THAP11, CTNNB1, BCL6, CEBPA, NKX2-2, EZH2phosphoT487, SIN3A, ZFX, AFF4, SOX13, SMAD3, SMARCC1, PRDM10, RARA, ZNF35, CREBBP, GATA4, OSR2, ZNF184, PBX4, DAXX, ATF2, PRDM9, ZEB2, SMAD4, ZNF48, MAFB, FOS, MED1, TEAD3, CEBPD, SCRT2, PIAS1, NR1H2, SETDB1, SREBF2, ZNF22, NIPBL, SP1, BCL11A, HNF4A, IKZF5, REST, ASH2L, PHIP, GLIS2, FOXP1, PRDM6, SMC3, NCOR2, STAG2, ZNF394, SKI, PPARG, FOXA2, PAF1, ZNF600, ZNF692, ZSCAN16, WT1, ESR2, ZBTB33, HOXB13, ZNF580, KDM1A, YY1, RELA, NEUROD1, ISL1, TCF4, OTX2, TAL1, MAX, HAND2, CBX2, TLE3, KLF4, ZFP69B, SP7, CEBPG, NR2F2, NEUROG2, TCF7L2, TP53, PKNOX1, ZNF334, MYOD1, PHOX2B, ELF3, ZNF843, KAT8, ARRB1, ARID4B, AR, NFKBIZ, TAF1, ZBTB40, RXR, ZNF324, ZNF366, EGR1, ZBTB26, NCOR1, JUND, SCRT1, BRD4, CUX1, MAZ, ZSCAN23, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): PDE9A,SLC37A1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 78
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000160190, ENSG00000160191,
  • Related loop: chr21:42575000-42600000~~chr21:42700000-42725000, chr21:42575000-42600000~~chr21:42725000-42750000, chr21:42600000-42625000~~chr21:42700000-42725000, chr21:42600000-42625000~~chr21:42725000-42750000, chr21:42700000-42725000~~chr21:42800000-42825000, chr21:42725000-42750000~~chr21:43175000-43200000, chr21:42725000-42750000~~chr21:43200000-43225000, chr21:42725000-42750000~~chr21:43575000-43600000, chr21:6425000-6450000~~chr21:42725000-42750000,
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