Deatailed information for cohesin site CDBP00420457

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  • Basic information
  • CohesinDB ID: CDBP00420457
  • Locus: chr21-42722042-42725763
  • Data sourse: GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, GSE103477, GSE131606, GSE25021, ENCSR000EDW, GSE165895, ENCSR000BTU, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, ENCSR167MTG, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990
  • Cell type: MCF-7, RPE, Hela-Kyoto, Fibroblast, HCT-116, Hep-G2, RH4, THP-1, Ishikawa, RT-112, K-562, HSPC, HuCC-T1, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 12% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.844
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 86% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 30%, "5_TxWk": 30%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, FOSL1, SMARCA2, HMG20A, E2F7, XBP1, HNF1A, FOXA1, RXRB, MLL4, ZFHX2, TFAP4, ATF3, ZC3H8, THRB, CHD7, RUNX3, ATF4, KLF14, CBFB, MXD4, MITF, CDX2, JMJD1C, MYOG, KLF5, TEAD1, ELF1, MAF, KLF6, ETV1, NFE2L2, RCOR2, ESR1, OCA2, MED26, HNF1B, LMO2, CTCF, JUN, TCF12, BAF155, EP300, SOX9, GATA6, SOX5, PAX8, SOX4, DMAP1, E2F1, ZNF528, SMC1, TEAD4, FOXA3, KMT2B, ZNF175, GATAD2A, GTF2F1, TFAP2C, RBPJ, EED, MLX, POU2F2, CHD8, MYCN, RUNX1T1, ID3, ZNF317, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, ARID3A, HNF4G, ERG, PAX6, HOXC5, PBX1, NFKB2, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, PROX1, NKX2-1, RXRA, STAT3, APC, ZNF614, XRCC5, PRDM14, GFI1, MIER3, DNMT3B, NR2F6, IKZF1, VDR, RCOR1, NR3C1, CEBPB, NFE2, HNRNPL, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, ZNF652, MRTFA, GABPB1, ZHX2, SPI1, TFE3, EHF, MIXL1, IRF1, HDAC2, GATA2, ZNF644, MXD3, FLI1, SREBF1, DRAP1, ZGPAT, MRTFB, NFIL3, NCOA2, MYF5, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, EZH2phosphoT487, SOX13, ZFX, FIP1L1, SIN3A, SMAD3, TET2, ERG3, SP5, SMARCC1, RARA, PRPF4, CREBBP, RUNX2, CDK6, GATA4, OSR2, NRF1, PBX4, DAXX, BACH1, ARNT, ZNF48, HMGB2, SMAD4, FOXM1, SP2, SMARCB1, FOS, HMGXB4, CDK8, MED1, TEAD3, ZEB1, SPDEF, MYB, NR1H2, KLF9, HIF2A, RBM22, MAFK, NIPBL, SP1, HNF4A, IKZF5, ARID1A, ZNF479, POU2F3, ASH2L, PHIP, TCF3, FOXP1, AATF, SMC3, ELL2, NCOR2, STAG1, ETV4, SKI, TRP47, PPARG, FOXA2, CBX3, EBF1, MEIS1, PAF1, CREM, ZNF600, MIER2, GTF2B, WT1, MAFF, ZSCAN16, ZNF580, KDM1A, YY1, RELA, SP140, ZIC2, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, MTA1, CBX2, CEBPG, KLF4, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, NEUROG2, TP53, MED, MYOD1, EGR2, ELF3, BRD2, KAT8, PHF5A, ARID4B, AR, BHLHE40, NFKBIZ, RXR, YAP1, EGLN2, ZBTB42, HEXIM1, EGR1, ZBTB26, HSF1, NCOR1, BRD4, JUND, MAZ, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): PDE9A,SLC37A1,HSF2BP
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 65
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160207,
  • Related loop: chr21:42575000-42600000~~chr21:42700000-42725000, chr21:42575000-42600000~~chr21:42725000-42750000, chr21:42600000-42625000~~chr21:42700000-42725000, chr21:42600000-42625000~~chr21:42725000-42750000, chr21:42700000-42725000~~chr21:42800000-42825000, chr21:42725000-42750000~~chr21:43175000-43200000, chr21:42725000-42750000~~chr21:43200000-43225000, chr21:42725000-42750000~~chr21:43575000-43600000, chr21:6425000-6450000~~chr21:42725000-42750000,
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