- Basic information
- CohesinDB ID: CDBP00420459
- Locus: chr21-42735915-42736171
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Data sourse: GSE206145-NatGen2015, GSE67783
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Cell type: Fibroblast, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 0% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SA1,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 35%,
"4_Tx": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, LCORL, SOX2, XBP1, HNF1A, FOXA1, HLF, SUZ12, RBFOX2, RXRB, PBX2, KDM3A, TFAP4, TSC22D4, ATF3, NFIC, THRB, ZFP64, HNRNPUL1, THAP1, CHD7, RUNX3, CBFB, MXD4, MECOM, TP63, HDAC3, CDX2, MAF, JMJD1C, KLF5, TEAD1, ELF1, INTS11, KLF6, ETV1, NFE2L2, RBM39, RCOR2, ESR1, HNF1B, OCA2, KLF10, CTCF, JUN, TCF12, BAF155, EP300, MNT, SOX9, GATA6, SOX5, LMO1, DMAP1, E2F6, IRF4, TRIM24, E2F4, E2F1, RFX3, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, PDX1, TFAP2C, RBPJ, MLX, GTF2F1, NANOG, CHD8, BRD1, POU2F2, MYCN, ZNF263, POU5F1, RUNX1T1, CDK7, ERF, ZBTB48, STAT1, NONO, SRF, GATAD1, SAP130, ZNF485, ARID3A, DDX5, TBP, HNF4G, ERG, HOXC5, OGG1, ETS1, MYC, ONECUT1, SMARCA4, HOMEZ, RAD21, ARID1B, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, MCRS1, STAT3, ZNF614, XRCC5, NKX3-1, RCOR1, DNMT3B, NR2F6, MIER3, VDR, NFE2, NR3C1, CEBPB, ZNF750, HNRNPH1, STAT5B, HNRNPL, KMT2A, CREB1, CCAR2, SRSF3, EZH2, TBL1XR1, BMPR1A, GRHL2, ZNF652, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, HBP1, HDAC2, GATA2, SSRP1, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, MXI1, NFIL3, NCOA2, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, SOX13, ZFX, SIN3A, FIP1L1, SMAD3, TET2, CBX8, TBX3, SP5, SMARCC1, MYBL2, CREBBP, PRPF4, RARA, NFYC, ZNF384, NOTCH1, RUNX2, TAF15, GATA4, GR, NRF1, PBX4, ARNT, BACH1, ATF2, ZNF48, SMAD4, FOXM1, MAFB, FOS, HMGXB4, CDK8, SUPT5H, TGIF2, MED1, CHD1, ZEB1, TEAD3, MYB, SCRT2, PIAS1, ZMYM3, U2AF1, ZNF3, NR1H2, L3MBTL2, MBD1, RBM22, MAFK, NIPBL, SP1, GSPT2, HNF4A, BCL11A, TRIM28, IKZF5, REST, ARID1A, ZBTB7A, ATF7, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, AATF, SMC3, STAG1, ETV4, NFATC3, SKI, PAX7, TRP47, CBFA2T2, PPARG, FOXA2, ZNF316, CREM, MEIS1, PAF1, AGO1, MIER2, ZNF600, ZSCAN16, WT1, MAFF, FOXF1, ZBTB33, TCF7, MEF2C, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, JUNB, BRG1, MCM3, SP140, TCF4, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, AGO2, CBX2, TLE3, KLF4, CEBPG, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, ZNF334, ELF3, PHF5A, KAT8, ARRB1, TBX21, ARID4B, AR, NFKBIZ, TAF1, ZNF579, RXR, EGLN2, EGR1, HEXIM1, ZBTB26, NCOR1, HSF1, JUND, BRD4, SCRT1, CUX1, MAZ, SMAD4.1D12, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SLC37A1,HSF2BP,PDE9A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 13
- Number of somatic mutations (non-coding): 0
- Related genes and loops