Deatailed information for cohesin site CDBP00420469

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00420469
  • Locus: chr21-42753545-42754647
  • Data sourse: GSE67783, GSE86191, GSE111913, GSE206145-NatGen2015, ENCSR153HNT
  • Cell type: Fibroblast, HCT-116, RT-112, K-562, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 2% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.944
  • Subunit: SA1,Rad21,SA2,SMC1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 40%, "15_Quies": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, FOSL1, PGR, HMG20A, ZNF621, NME2, XBP1, FOXA1, SUZ12, RBFOX2, PBX2, RXRB, UBTF, ZFHX2, KDM3A, TFAP4, ZBTB7B, HDGF, TSC22D4, ATF3, BMI1, THRB, ZFP64, THAP1, CTCFL, RUNX1T1, CHD7, ZNF444, KLF14, CBFB, MXD4, SMARCE1, ZSCAN4, TP63, MITF, ZNF736, CDC5L, ZNF467, MAF, JMJD1C, ELF1, BCLAF1, TEAD1, RBM39, KLF6, ZNF121, RCOR2, ESR1, MLL, OCA2, CTCF, TCF12, JUN, EP300, KLF1, E4F1, MNT, GATA6, SOX5, DPF2, PAX8, E2F6, DMAP1, TRIM24, RFX5, ZNF512B, TEAD4, FOXA3, ZNF175, GATAD2A, EHMT2, RBPJ, TFAP2C, MLX, YBX1, GLIS1, JARID2, POU2F2, NANOG, BRD1, ZSCAN5D, POU5F1, ZNF263, MYCN, TOP2A, ID3, CTBP1, ZBTB1, MTA2, ZBTB48, ZSCAN5A, STAT1, DUX4, NONO, ZBTB17, GATAD1, DDX5, SAP130, ERG2, ARID3A, TBP, ZNF300, ERG, HNF4G, PBX1, ASCL1, OGG1, ETS1, MYC, ONECUT1, SMARCA4, RFX1, ARID1B, RAD21, HOMEZ, GRHL3, RXRA, STAT3, ZNF8, XRCC5, ZNF614, PRDM14, IKZF1, NFE2, DNMT3B, NR2F6, HNRNPH1, RCOR1, ZNF639, NR3C1, ESRRA, SRSF3, MIER3, HNRNPL, CEBPB, KMT2A, CREB1, EZH2, KLF8, GRHL2, ZNF652, GABPB1, ZHX2, HES1, SPI1, TFE3, MIXL1, IRF1, PCBP1, HDAC2, GATA2, SSRP1, ZNF644, GATAD2B, MXD3, SIX2, FLI1, HCFC1, ZNF785, ZGPAT, DRAP1, MXI1, NFIL3, NCOA2, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, HDAC1, SIRT6, NKX2-2, CRY1, CEBPA, ZFX, SOX13, SIN3A, ZNF534, FIP1L1, SMAD3, TET2, ERG3, NFXL1, SP5, SMARCC1, PRDM10, RARA, CREBBP, ZBTB2, ZNF384, TAF15, RUNX2, GATA4, ARNT, NFIB, ZBTB10, ZNF48, ATF2, SMAD4, PRDM9, CBFA2T3, PBX3, SP2, FOS, CHD1, HMGXB4, SMARCB1, ZEB1, TEAD3, KDM6B, MYB, TERF1, U2AF1, KLF9, ZNF41, L3MBTL2, TBX5, RBM22, USF1, SP1, BCL11A, VDR, NR4A1, HNF4A, IKZF5, REST, ZNF479, ZBTB7A, NKX2-5, ARID2, ATF7, ASH2L, HNRNPLL, TCF3, BCOR, GLIS2, FOXP1, AATF, SMC3, STAG1, MLLT1, ZNF394, NFATC3, TRP47, CBFA2T2, NCOA4, PPARG, FOXA2, AGO1, MTA3, CHD2, PAF1, EBF1, ZNF207, MIER2, ZNF600, WT1, CREM, NFATC1, ZNF662, ZBTB33, MEF2C, HOXB13, ZKSCAN1, ZNF580, KDM1A, YY1, RELA, BCL3, TARDBP, NEUROD1, KAT2B, JUNB, MCM3, SP140, HIF1A, GATA3, ZNF311, MGA, MAF1, MAX, TAL1, ZNF143, AGO2, GATA1, CBX2, PLAG1, ZFP69B, KLF4, CEBPG, NCOA3, NR2F2, GFI1B, NR2F1, NEUROG2, KDM5B, TP53, PKNOX1, ZNF334, MYOD1, EGR2, PHOX2B, PHF5A, ELF3, KAT8, T, BHLHE40, AR, NFKBIZ, ARID4B, ZBTB40, RXR, EGLN2, ZNF366, HEXIM1, EGR1, HSF1, ZBTB26, RNF2, BRD4, JUND, MYNN, SCRT1, CUX1, MAZ, NCOR1, CLOCK, TBX2, BRCA1, ZFP42, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): ABCG1,C2CD2,SLC37A1,PDE9A
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 455
  • Number of somatic mutations (non-coding): 35
  • Related genes and loops
  • Related gene: ENSG00000157617, ENSG00000160179, ENSG00000160190, ENSG00000160191,
  • Related loop: chr21:27500000-27525000~~chr21:42750000-42775000, chr21:41900000-41925000~~chr21:42750000-42775000, chr21:42275000-42300000~~chr21:42750000-42775000, chr21:42300000-42325000~~chr21:42750000-42775000, chr21:42575000-42600000~~chr21:42725000-42750000, chr21:42575000-42600000~~chr21:42750000-42775000, chr21:42600000-42625000~~chr21:42725000-42750000, chr21:42725000-42750000~~chr21:43175000-43200000, chr21:42725000-42750000~~chr21:43200000-43225000, chr21:42725000-42750000~~chr21:43575000-43600000, chr21:42750000-42775000~~chr21:43175000-43200000, chr21:6425000-6450000~~chr21:42725000-42750000,
eachgene