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Basic information

CohesinDB ID: CDBP00420478

Locus: chr21-42776828-42779070

Data sourse: ENCSR000BTU, GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE25021, GSE50893

Cell type: MCF-7, RPE, Fibroblast, HCT-116, GM2610, Ishikawa, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 32%, "14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, POU5F1, MYCN, ID3, ZFX, XBP1, GTF2B, ZBTB48, WT1, STAT1, FOXA1, ZNF205, TET2, CBX8, SUZ12, ERG, RELA, ZNF384, ATF3, EZH1, MYC, AHR, ZNF2, SP140, GRHL3, XRCC5, ZNF143, GATA1, FOS, DNMT3B, TERF2, CBX2, ELF1, TRIM28, EZH2, KLF9, CTCF, SPI1, KLF1, AR, HSF1, RNF2, ZNF605, MAZ, ZNF92, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): UMODL1,PDE9A,ABCG1,SLC37A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191,

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Deatailed information for cohesin site CDBP00420478