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Basic information

CohesinDB ID: CDBP00420484

Locus: chr21-42790449-42793799

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE132649, ENCSR000EGW, GSE105028, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, GSE115602, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE116344, GSE145327, ENCSR000EEG, ENCSR338DUC, ENCSR193NSH, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR748MVX, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE129526, ENCSR676MJK, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS

Cell type: RH4, GM2610, GM19240, HSPC, HuCC-T1, H9-hESC, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, K-562, GM18486, DKO, GM18526, H1-hESC, GM12878, RT-112, HeLa-Tet-On, GM19099, HUES64, MCF-7, GM12892, T-47D, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, GM19238, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 28% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.644

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 37%, "14_ReprPCWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: POU2F2, PGR, TOP2A, SIN3A, ZFX, ZNF600, ZBTB48, FOXA1, HLF, ZNF770, DDX5, SUZ12, HOXB13, PRDM10, ERG, RELA, SP140, NRF1, ARNT, GRHL3, ZNF354A, TP63, ZNF750, KLF4, JMJD1C, KLF5, CEBPB, TEAD3, NCOA3, CREB1, EZH2, TP53, ESR1, OCA2, PHOX2B, CTCF, AR, HDAC2, REST, ZNF479, ZNF182, BRD4, ZNF528, ZIM3, AHR

Target gene symbol (double-evidenced CRMs): ABCG1,SLC37A1,UMODL1,PDE9A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 22

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191,

eachgene

Deatailed information for cohesin site CDBP00420484