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Basic information

CohesinDB ID: CDBP00420486

Locus: chr21-42796065-42797183

Data sourse: GSE72082, GSE67783, GSE86191, ENCSR054FKH, ENCSR153HNT, GSE68388

Cell type: HCT-116, Hep-G2, K-562, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 38%, "14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, HMG20A, XBP1, FOXA1, HLF, RXRB, MLL4, TFAP4, NFIC, ZFP64, THAP1, SMARCE1, JMJD1C, TEAD1, TRIM28, ELF1, ESR1, OCA2, CTCF, TCF12, LMO1, GATA6, SOX5, DPF2, TRIM24, RFX5, SOX6, ZNF528, TEAD4, FOXA3, GATAD2A, MYCN, ID3, CTBP1, STAT1, SAP130, DDX5, SMARCA4, ARID1B, PROX1, GABPA, XRCC5, IKZF1, RCOR1, NR2F6, NR3C1, CEBPB, CREB1, EZH2, GRHL2, SPI1, IRF1, HDAC2, GATA2, ZNF644, RUNX1, BCL6, HDAC1, CEBPA, SIRT6, SOX13, ZFX, CBX8, SMARCC1, PRDM10, ZNF35, ZNF384, RUNX2, GATA4, SMAD4, ZEB2, CBFA2T3, MED1, ZEB1, TEAD3, PML, MYB, NCOA1, ZNF22, BCL11A, ARID1A, TCF3, CBFA2T2, FOXA2, ZNF600, ESR2, KDM1A, ZNF282, ZFP36, TAL1, GATA1, ZNF143, CEBPG, GFI1B, NCOA3, NR2F2, NR2F1, TP53, ELF3, EGLN2, BRD4

Target gene symbol (double-evidenced CRMs): PDE9A,UMODL1,SLC37A1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160179, ENSG00000160190, ENSG00000160191,

eachgene

Deatailed information for cohesin site CDBP00420486