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Basic information

CohesinDB ID: CDBP00420491

Locus: chr21-42807469-42808220

Data sourse: ENCSR167MTG, ENCSR338DUC, GSE72082, GSE111913, ENCSR000BLS, ENCSR054FKH, ENCSR153HNT, GSE25021

Cell type: K-562, RT-112, Hep-G2

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 34%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: HMG20A, SOX2, FOXA1, RXRB, ZFP64, THAP1, CHD7, JMJD1C, TEAD1, TRIM28, LMO2, ESR1, RCOR2, CTCF, TCF12, EP300, GATA6, SOX5, E2F6, ZNF528, TEAD4, ZNF175, GATAD2A, RBPJ, EED, MLX, JARID2, NANOG, CHD8, POU5F1, MYCN, RUNX1T1, ZBTB48, SAP130, ERG, EOMES, RAD21, GABPA, NFE2, NR2F6, CREB1, SPI1, MIXL1, TFE3, HDAC2, GATA2, FLI1, RUNX1, THAP11, CTNNB1, SMC1A, BCL6, CEBPA, SOX13, ZFX, SMAD3, TET2, CREBBP, SMAD2, CDK6, SMAD4, HMGXB4, TEAD3, BCL11A, IKZF5, ARID1A, BCOR, TCF3, SMC3, ZNF207, FOXA2, WT1, HOXB13, YY1, RELA, NEUROD1, SP140, HIF1A, OTX2, MAX, CBX2, CEBPG, NCOA3, ZNF334, ELF3, T, KAT8, NFKBIZ, AR, ARID4B, ZBTB26, ZFP42, DMAP1

Target gene symbol (double-evidenced CRMs): BACE2,SLC37A1,PRDM15,TMPRSS3,HSF2BP,TFF2,PDE9A,UMODL1,FAM3B,ABCG1,UBASH3A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000141956, ENSG00000177398, ENSG00000160179, ENSG00000160181, ENSG00000160183, ENSG00000160185, ENSG00000160190, ENSG00000160191, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420491