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Basic information

CohesinDB ID: CDBP00420492

Locus: chr21-42809607-42810029

Data sourse: GSE67783, GSE111913, GSE206145, ENCSR153HNT, GSE25021

Cell type: MCF-7, RPE, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 40%, "13_ReprPC": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF621, XBP1, FOXA1, SUZ12, ZSCAN4, ZNF121, SNAI2, LMO2, ESR1, OCA2, TP73, JUN, CTCF, EP300, MNT, PAX8, EED, GLIS1, NANOG, POU2F2, BRD1, CHD8, ZNF263, POU5F1, MYCN, ZBTB48, DDX5, SP4, ERG, ZNF341, EZH1, MYC, SMARCA4, RAD21, GRHL3, GABPA, ARNTL, NR3C1, CREB1, EZH2, SPI1, SSRP1, GATA2, NCOA2, RUNX1, SMC1A, BCL6, CRY1, ZFX, POU4F2, ZNF770, TET2, ZNF384, CDK6, ARNT, ETV6, PBX3, FOS, MED1, ZNF680, ZNF3, NCOA1, SETDB1, BCL11A, GSPT2, ARID2, TCF3, SMC3, STAG1, TRP47, PPARG, TBL1X, FOXA2, NFATC1, GTF2B, ZNF30, WT1, CDK9, BCL3, KDM1A, YY1, RELA, MCM3, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, MAF1, NRIP1, ZNF143, GATA1, KLF4, NCOA3, NR2F1, TP53, ZNF334, AR, ZBTB26, JUND, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): UBASH3A,BACE2,SLC37A1,PRDM15,UMODL1,TMPRSS3,TFF2,ABCG1,HSF2BP,FAM3B,PDE9A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000141956, ENSG00000177398, ENSG00000160179, ENSG00000160181, ENSG00000160183, ENSG00000160185, ENSG00000160190, ENSG00000160191, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420492