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Basic information

CohesinDB ID: CDBP00420499

Locus: chr21-42828509-42829093

Data sourse: GSE206145-GSE177045, GSE67783, ENCSR153HNT

Cell type: K-562, MCF-7, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: Mau2,SA1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 55%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, KDM3A, ZBTB7B, HDGF, TASOR, THAP1, IKZF3, MORC2, PAX5, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, E4F1, SOX5, PAX8, ZNF407, DEK, ZNF528, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ZMYND11, STAT1, SAP130, ERG, NFKB2, EZH1, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, ELF4, MIXL1, GATA2, MXD3, FLI1, HCFC1, MXI1, HCFC1R1, RUNX1, HDAC1, CEBPA, NKX2-2, CRY1, TET2, SP5, TRIM22, PRDM10, ZBTB2, ATF2, SNIP1, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, ARID2, IKZF5, MBD2, ELL2, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, SS18, ZSCAN16, WT1, MEF2C, MPHOSPH8, NEUROD1, JUNB, ZFP36, TCF4, ZNF311, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, XBP1, KDM4B, SRSF4, PBX2, HNRNPK, ATF3, THRB, HNRNPUL1, RUNX3, CBFB, TP63, ZSCAN4, MITF, CDC5L, JMJD1C, MAF, MYOG, ELF1, RBM39, SNAI2, SMAD5, JUN, CTCF, LMO1, MNT, DPF2, IRF4, ZNF423, RBPJ, TFAP2C, YBX1, ZNF317, ZBTB17, ZBTB48, ZSCAN21, MTA2, NONO, SRF, DDX5, NBN, PHB2, PBX1, ONECUT1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, KLF8, ARHGAP35, GRHL2, EBF3, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, AFF4, SOX13, POU4F2, ZNF770, ZNF18, EWSR1, ARNT, BACH1, NFIB, ZNF48, PRDM9, HMBOX1, NFYA, PBX3, NCAPH2, HMGXB4, TEAD3, U2AF1, KLF9, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAT2, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF441, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, BRD4, JUND, ZSCAN23, PGR, SOX2, PATZ1, LEO1, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ERG2, SP4, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, NFXL1, CREBBP, ZNF384, RARA, ZNF35, TAF15, ZNF169, SMAD4, CDK8, SNRNP70, CSNK2A1, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF692, GTF2B, ZNF574, ZNF662, FOXO3, RELA, TARDBP, ZNF282, MAX, ZNF223, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZBTB16, YAP1, ZNF324, HEXIM1, AHR, FOSL2, MBD3, HMG20A, LCORL, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, ZNF274, NFIC, ZNF362, CTCFL, ZBTB5, KLF14, GLYR1, ZNF736, TRIM28, BCLAF1, ETV1, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, FEZF1, HES1, IRF1, SREBF1, ZGPAT, ZNF418, MRTFB, MYF5, PTBP1, SMC1A, MAFG, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, PCBP2, NSD2, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, NRF1, SUPT5H, FOS, CHD1, MED1, ZNF7, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, TCF3, SKI, PAX7, ZNF283, NCOA4, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, BRCA1, SP140, HIF1A, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RRP1B,MX1,SLC37A1,UMODL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000157601, ENSG00000177398, ENSG00000160190, ENSG00000160208,

eachgene

Deatailed information for cohesin site CDBP00420499