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Basic information

CohesinDB ID: CDBP00420518

Locus: chr21-42877653-42880442

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE62063, ENCSR495WGO, ENCSR000BTQ, GSE38395, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, ENCSR676MJK, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 36% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.356

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 33%, "1_TssA": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, MORC2, PAX5, SFPQ, TEAD1, SNAPC1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, ARID5B, SOX5, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, ZMYND11, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, ZNF785, RELB, EP400, RUVBL2, RUNX1, CEBPA, HDAC1, NKX2-2, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, ZNF584, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, ARID2, IKZF5, OVOL3, RBM25, ZSCAN31, AFF1, MBD2, ELL2, ZNF704, ETV4, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, SRSF4, PBX2, HNRNPK, THRB, ATF3, ZC3H8, ZFP64, RUNX3, WDHD1, CBFB, DPF1, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, NBN, ZNF2, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, LEF1, MIER3, HNRNPH1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, ZNF669, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, AFF4, SOX13, POU4F2, ZMIZ1, ZNF18, SP3, ARNT, BACH1, NFIB, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, ZBTB18, TBX5, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, MLLT1, STAG1, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, KLF7, BCL3, KDM1A, ZKSCAN1, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF645, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, IRF9, ZFP42, PGR, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, SND1, KLF1, ZNF260, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, ERG2, HIC1, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, TAF9B, ZNF76, NFYB, NCOA2, ZNF554, ETV5, AHRR, BCL6, SIN3A, ERG3, CREBBP, ZNF384, NFYC, ZNF35, RARA, TAF15, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZNF264, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, YY2, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, PKNOX1, RUVBL1, MYOD1, T, AR, KMT2D, YAP1, ZNF324, RBAK, HEXIM1, ZNF395, DMAP1, AHR, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, SFMBT1, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, KLF14, MECOM, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, GMEB2, ARID3A, MIER1, ZNF341, ZNF84, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ARNTL, ZNF750, ZNF501, FEZF1, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, MRTFB, ZC3H11A, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, CDK6, OSR2, ZNF184, GATA4, NRF1, SUPT5H, CHD1, FOS, TGIF2, MED1, CEBPD, MYB, KDM6B, SCRT2, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, TAF2, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF837, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): HSF2BP,CSTB,RRP1,DNMT3L,UBE2G2,WDR4,SUMO3,RRP1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 52

Number of somatic mutations (non-coding): 37

Related genes and loops

Related gene: ENSG00000160193, ENSG00000160207, ENSG00000160208, ENSG00000160213, ENSG00000160214, ENSG00000142182, ENSG00000184787, ENSG00000184900,

eachgene

Deatailed information for cohesin site CDBP00420518