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Basic information

CohesinDB ID: CDBP00420533

Locus: chr21-42909724-42911164

Data sourse: GSE67783, GSE76815, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC, SK-N-SH

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 69%, "5_TxWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, XBP1, FOXA1, RBFOX2, LEO1, HDGF, ZFP64, ZNF362, ZNF322, CBFB, ZNF189, MECOM, TP63, KLF5, ZNF121, ZNF573, RBM39, SMAD5, ESR1, OCA2, TP73, ZBTB49, CTCF, JUN, PAX8, ZNF528, TEAD4, TFAP2C, EED, GLIS1, CDK9-HEXIM1, POU2F2, CHD8, ZSCAN5D, ZNF263, MYCN, RUNX1T1, TOP2A, ZSCAN21, ZBTB17, DUX4, ZBTB48, ZSCAN5A, ZNF563, DDX5, ERG2, ERG, MYC, SMARCA4, APC, NKX3-1, ZNF667, HNRNPH1, EZH2, ZHX2, SPI1, ZNF664, GATA2, SIX2, FLI1, ZNF766, NCOA2, RUNX1, BCL6, SMC1A, ZFX, ERG3, PRDM10, NSD2, ZNF384, ZNF133, RUNX2, CDK6, OSR2, PBX4, ARNT, ZNF48, SUPT5H, CDK8, MED1, TEAD3, SUPT16H, ZNF22, RBM22, BCL11A, NIPBL, ARID1A, FOXP1, SMC3, STAG1, MLLT1, ZNF394, TRP47, TBL1X, MTA3, PAF1, E2F8, NFATC1, WT1, MEF2C, HOXB13, MPHOSPH8, YY1, RELA, NEUROD1, ZNF510, SP140, MAX, AGO2, NCOA3, KDM5B, TP53, PHOX2B, AR, ZBTB42, MYNN, NCOR1, BRD4, ILF3, MAZ

Target gene symbol (double-evidenced CRMs): HSF2BP,CBS,RRP1B,U2AF1,NDUFV3,PKNOX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 15

Number of somatic mutations (non-coding): 15

Related genes and loops

Related gene: ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160201, ENSG00000160207, ENSG00000160208,

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Deatailed information for cohesin site CDBP00420533