- Basic information
- CohesinDB ID: CDBP00420541
- Locus: chr21-42928933-42932902
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Data sourse: GSE93080, ENCSR167MTG, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE111913, ENCSR879KXD, GSE206145, GSE85526, ENCSR000EDE, ENCSR153HNT, ENCSR000ECS, GSE165895
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Cell type: RPE, Hela-Kyoto, HCT-116, HEKn, Hep-G2, GM12878, HeLa-S3, RT-112, K-562, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 49%,
"5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, MLL4, KDM3A, HDGF, ZBTB44, IKZF3, PAX5, ZNF320, ZNF121, OCA2, E4F1, ARID5B, ZNF75A, ZNF407, DEK, E2F4, ZNF528, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, BRD3, TOP2A, CTBP1, STAT1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, DNMT1, FOXK2, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, CREB1, GABPB1, ELF4, ZHX2, MIXL1, KLF17, GATA2, FLI1, HCFC1, ZNF785, NR2C2, RELB, EP400, RUNX1, HDAC1, NKX2-2, ZNF707, REPIN1, ZNF654, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ELK1, ATF2, FOXM1, SP2, GMEB1, PML, ZNF331, SMAD1, C11orf30, EVI1, ARID2, IKZF5, AFF1, THRA, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, TCF4, ZFP36, SPIB, KLF4, ZFP69B, BCL11B, ZNF281, MED, EGR2, ELF3, ARID4B, EGLN2, ZNF366, HSF1, NCOR1, ILF3, ZNF316, XBP1, KDM4B, PBX2, ATF3, ZC3H8, ZFP64, RUNX3, CBFB, ZSCAN4, ZNF467, CDC5L, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, ZBTB20, MNT, LMO1, RYBP, DPF2, IRF4, ZNF423, PDX1, RBPJ, TFAP2C, ZNF239, MTA2, ZNF317, ZBTB17, ZBTB48, ZSCAN21, SRF, DDX5, NBN, PHB2, PBX1, ONECUT1, TSHZ1, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, LEF1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, KLF8, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, AFF4, ZNF770, ZMIZ1, ZNF18, SP3, NFIB, ARNT, HMBOX1, NFYA, ZEB2, ETV6, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, ZNF623, SMC3, STAG2, STAG1, MLLT1, ZNF394, TRP47, MTA3, EBF1, MAFF, ZNF580, KLF7, ZKSCAN1, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, NFKB1, ZSCAN22, ZNF140, BRD2, KAT8, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, ZSCAN23, PGR, SOX2, PATZ1, TFAP4, CHD7, ZNF444, ATF4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, E2F6, TRIM24, RFX5, GLIS1, POU2F2, ZSCAN5D, ZNF778, ASH1L, ZSCAN5A, ELK4, ZMYND8, ERG2, SP4, TBP, HOXC5, SMARCC2, ETS1, MYC, ZNF671, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, SRSF3, EZH2, PHF8, SPI1, HDAC2, GATAD2B, ZNF76, NFYB, ZNF554, ETV5, BCL6, SIN3A, ERG3, NFXL1, MEF2A, CREBBP, ZNF35, ZNF384, RARA, HMGB2, ZNF518A, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, ZNF22, MAFK, HNF4A, REST, ARID1A, ZHX1, BCOR, FOXP1, ZNF816, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, RELA, TARDBP, SKIL, MGA, MAX, ZNF223, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, AR, ZNF324, ZZZ3, AHR, E2F7, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, INSM2, NFIC, ZNF362, CTCFL, PRDM1, MECOM, ZNF736, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, TCF12, EP300, BAF155, GATA6, PRDM4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, CDK7, RUNX1T1, MLLT3, GATAD1, ARID3A, ZNF341, EOMES, RAD21, XRCC5, ZNF614, NFE2, ZNF639, TFE3, EHF, ZGPAT, ZNF418, MRTFB, ATF1, SMC1A, CBX1, ZNF335, ZFX, SMAD3, IRF2, ZNF701, NOTCH1, BRD9, RUNX2, SMAD2, GATA4, OSR2, ZNF184, PBX4, NR2C1, SUPT5H, CHD1, MED1, ZNF558, MYB, CEBPD, VEZF1, ZNF3, L3MBTL2, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SKI, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, HIF1A, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, MAZ, MEF2D, ZNF24
- Target gene symbol (double-evidenced CRMs): CBS,RRP1B,PKNOX1,HSF2BP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 13
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160208,
- Related loop:
chr21:27500000-27525000~~chr21:42925000-42950000,
chr21:42900000-42925000~~chr21:43000000-43025000,
chr21:42900000-42925000~~chr21:43025000-43050000,
chr21:42900000-42925000~~chr21:43100000-43125000,
chr21:42900000-42925000~~chr21:43175000-43200000,
chr21:42900000-42925000~~chr21:43200000-43225000,
chr21:42900000-42925000~~chr21:43300000-43325000,
chr21:42900000-42925000~~chr21:43325000-43350000,
chr21:42900000-42925000~~chr21:43350000-43375000,
chr21:42900000-42925000~~chr21:43600000-43625000,
chr21:42900000-42925000~~chr21:43625000-43650000,
chr21:42900000-42925000~~chr21:43650000-43675000,
chr21:42922609-42925287~~chr21:43644896-43647868,
chr21:42922692-42925178~~chr21:43644727-43647870,
chr21:42922930-42925162~~chr21:43644933-43647734,
chr21:42922962-42925091~~chr21:43644228-43647626,
chr21:42922972-42925217~~chr21:43644939-43647696,
chr21:42923020-42925261~~chr21:43644178-43647643,
chr21:42925000-42950000~~chr21:43025000-43050000,
chr21:42925000-42950000~~chr21:43175000-43200000,
chr21:42925000-42950000~~chr21:43300000-43325000,
chr21:42925000-42950000~~chr21:43325000-43350000,
chr21:42925000-42950000~~chr21:43350000-43375000,
chr21:42925000-42950000~~chr21:43575000-43600000,
chr21:42925000-42950000~~chr21:43625000-43650000,
chr21:42925000-42950000~~chr21:43650000-43675000,
chr21:42925000-42950000~~chr21:43675000-43700000,
chr21:42936873-42938284~~chr21:42956494-42958234,
chr21:6425000-6450000~~chr21:42900000-42925000,
chr21:6475000-6500000~~chr21:42900000-42925000,
chr21:6475000-6500000~~chr21:42925000-42950000,