- Basic information
- CohesinDB ID: CDBP00420543
- Locus: chr21-42936506-42943558
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR501LQA, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE25021, ENCSR330ELC, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, ENCSR806UKK, GSE112028, GSE138105, ENCSR199XBQ, GSE116344, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS, GSE64758
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Cell type: RH4, GM2610, SLK, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, H1-hESC, SNYDER, GM12891, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, HUES64, MCF-7, Ramos, Hela-Kyoto, HCT-116, A-549, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 24% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.700
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 39%,
"7_Enh": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZNF592, CEBPB, GATA4, PBX2, NR2C1
- Target gene symbol (double-evidenced CRMs): HSF2BP,PKNOX1,CBS,RRP1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 37
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160208,
- Related loop:
chr21:27500000-27525000~~chr21:42925000-42950000,
chr21:42925000-42950000~~chr21:43025000-43050000,
chr21:42925000-42950000~~chr21:43175000-43200000,
chr21:42925000-42950000~~chr21:43300000-43325000,
chr21:42925000-42950000~~chr21:43325000-43350000,
chr21:42925000-42950000~~chr21:43350000-43375000,
chr21:42925000-42950000~~chr21:43575000-43600000,
chr21:42925000-42950000~~chr21:43625000-43650000,
chr21:42925000-42950000~~chr21:43650000-43675000,
chr21:42925000-42950000~~chr21:43675000-43700000,
chr21:42936873-42938284~~chr21:42956494-42958234,
chr21:6475000-6500000~~chr21:42925000-42950000,