Deatailed information for cohesin site CDBP00420545

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  • Basic information
  • CohesinDB ID: CDBP00420545
  • Locus: chr21-42955236-42958765
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE64758, ENCSR760NPX, ENCSR150EFU, GSE105028, GSE121355, GSE62063, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, ENCSR000BTU, GSE115602, GSE25021, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR806UKK, GSE120943, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, ENCSR895JMI, ENCSR000EEG, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS, ENCSR481YWD
  • Cell type: RH4, CVB-hiPSC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, GM18486, H1-hESC, Monocytes, RT-112, Macrophage, HUES64, MCF-7, Ramos, Hela-Kyoto, HCT-116, Hep-G2, A-549, HeLa, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 37% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.700
  • Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES,Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 52%, "7_Enh": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, NFIA, FOSL1, PGR, HMG20A, SOX2, MEIS2, FOXA1, PBX2, RXRB, TFAP4, HDGF, MEN1, ATF3, NFIC, ZNF362, CHD7, WDHD1, SMARCE1, TP63, HDAC3, SFPQ, CDX2, JMJD1C, KLF5, ELF1, TEAD1, NFE2L2, ZNF217, ESR1, HNF1B, RCOR2, USF2, CTCF, TCF12, JUN, BAF155, EP300, E4F1, SOX9, GATA6, SOX5, DPF2, SOX4, E2F6, DMAP1, RFX5, SOX6, PRKDC, E2F1, NR5A2, SMC1, TEAD4, FOXA3, ZNF175, GTF2F1, GATAD2A, TFAP2C, RBPJ, NANOG, POU2F2, POU5F1, TOP2A, CTBP1, MTA2, ZBTB48, STAT1, SRF, GATAD1, SAP130, ARID3A, TBP, ERG, HOXC5, SMARCC2, ETS1, MYC, SMARCA4, ARID1B, RAD21, HOMEZ, RXRA, NKX2-1, FOXK2, GABPA, APC, STAT3, ZNF614, NKX3-1, IKZF1, RCOR1, NFE2, LEF1, NR2F6, MIER3, ZNF750, CEBPB, NR3C1, CREB1, GRHL2, TRPS1, ZHX2, HES1, TFE3, EHF, MIXL1, IRF1, HDAC2, GATA2, ZNF644, GATAD2B, DRAP1, ZGPAT, HCFC1, SMARCA5, NFIL3, NCOA2, ATF1, RUNX1, THAP11, CTNNB1, CBX1, BCL6, HDAC1, CEBPA, SMC1A, SIN3A, SOX13, AFF4, ZFX, SMAD3, TRIM22, CREBBP, ZXDC, RARA, ZBTB2, ZNF384, BRD9, RUNX2, SMAD2, GATA4, GR, ARNT, NFIB, PBX4, DAXX, BACH1, ATF2, SMAD4, ZEB2, CBFA2T3, FOXM1, SMARCB1, CDK8, FOS, HMGXB4, CHD1, MED1, GMEB1, TEAD3, PML, CEBPD, PIAS1, ZNF3, NR1H2, C11orf30, L3MBTL2, SETDB1, MAFK, NIPBL, SP1, USF1, HNF4A, TFAP2A, IKZF5, REST, ARID1A, ZHX1, ATF7, ASH2L, HNRNPLL, CTBP2, PHIP, MBD2, FOXP1, AFF1, BCOR, SMC3, ELL2, NCOR2, STAG1, MLLT1, STAG2, SKI, PPARG, CBX3, FOXA2, CREM, CHD2, PAF1, RBBP5, MAFF, WT1, ZBTB33, TCF7, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, BRCA1, TCF4, HIF1A, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, MTA1, TLE3, KLF4, CEBPG, NCOA3, NR2F2, ZNF512, TCF7L2, NR2F1, KDM5B, TP53, PKNOX1, NFKB1, BRD2, ELF3, KAT8, PHF5A, BHLHE40, AR, ARID4B, TAF1, ZNF579, ZBTB40, RXR, YAP1, EGLN2, NCOR1, RNF2, JUND, ILF3, BRD4, CLOCK, CUX1, MAZ, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): PDXK,CSTB,PKNOX1,SLC37A1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 18
  • Related genes and loops
  • Related gene: ENSG00000160190, ENSG00000160199, ENSG00000160209, ENSG00000160213,
  • Related loop: chr21:10325000-10350000~~chr21:42950000-42975000, chr21:42575000-42600000~~chr21:42950000-42975000, chr21:42936873-42938284~~chr21:42956494-42958234, chr21:42950000-42975000~~chr21:43175000-43200000, chr21:42950000-42975000~~chr21:43200000-43225000, chr21:42950000-42975000~~chr21:43275000-43300000, chr21:42950000-42975000~~chr21:43300000-43325000, chr21:42950000-42975000~~chr21:43750000-43775000, chr21:42954675-42957047~~chr21:42973040-42976308,
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