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Basic information

CohesinDB ID: CDBP00420553

Locus: chr21-42971699-42976556

Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE64758, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, GSE122299, GSE76893, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000EHW, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 50% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.289

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 26%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, ZNF383, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, E2F5, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, POU2F1, E4F1, ARID5B, SOX5, PYGO2, E2F4, DEK, ZNF528, KMT2B, GATAD2A, NANOG, POU5F1, BRD3, ZNF263, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, ZNF197, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZNF785, HCFC1, MXI1, RELB, EP400, RUNX1, ZMYM2, HDAC1, NKX2-2, CEBPA, CRY1, IRF3, REPIN1, TET2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, MBD1, STAT5A, IKZF5, ARID2, RBM25, ZNF605, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, ZNF207, CBX3, CREM, BRF2, PAF1, NFATC1, CHD2, ZSCAN16, WT1, MEF2C, MPHOSPH8, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, ZNF281, ZNF530, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, CBFB, ZNF273, DPF1, TP63, ZSCAN4, MITF, ZNF467, MAF, JMJD1C, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, DPF2, SIX5, IRF4, DDX20, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, MTA2, ZBTB17, ZBTB48, NONO, SRF, DDX5, NBN, PBX1, ONECUT1, ZNF2, HOMEZ, FOXP2, TSHZ1, KDM4A, RXRA, BATF3, NKX3-1, PRDM14, TEAD2, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, ARHGAP35, GRHL2, ZNF565, EBF3, ZBTB14, SSRP1, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, CEBPZ, SP3, ARNT, BACH1, NFIB, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, TFAP2A, SP1, ZNF479, ATF7, SALL4, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, BCL3, KAT2B, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, SPIN1, CUX1, ZSCAN23, IRF9, TBX2, ZFP42, PGR, SOX2, PATZ1, SNAPC4, RING1B, UBTF, LEO1, SIN3B, SETX, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, SND1, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ASH1L, ZSCAN5A, ZMYND8, HIC1, SP4, ERG2, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, ZNF343, DNMT3B, INO80, SRSF3, EZH2, ZNF652, NFE2L1, MRTFA, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, NFYB, NCOA2, ZNF76, ZNF554, ETV5, GTF2A2, BCL6, SIN3A, ERG3, RARA, ZNF384, CREBBP, NFYC, TAF15, ZNF35, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ILK, PTTG1, CXXC4, PPARG, TBL1X, HDAC6, ZNF44, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, YY2, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, RUVBL1, MYOD1, AR, KMT2D, YAP1, ZNF324, HEXIM1, ZNF395, AHR, DMAP1, MBD3, FOSL2, ZNF391, HMG20A, E2F7, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, INSM2, NFIC, ZNF362, ZBTB5, CTCFL, PRDM1, KLF14, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, CREB3, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, ATRX, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, CDK7, HINFP, GATAD1, GMEB2, ARID3A, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF750, ZNF501, HES1, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, ATF1, PTBP1, MAFG, CBX1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, GR, CDK6, NRF1, PBX4, NR2C1, CHD1, FOS, SUPT5H, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, ZNF283, KLF13, FOXA2, RBBP5, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, BRCA1, SP140, ZNF610, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, PTRF, TAF1, ZNF579, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF440, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): PFKL,SLC37A1,UMODL1,HSF2BP,CSTB,RRP1B,PDXK,CFAP410,TRPM2,DNMT3L,SUMO3,PKNOX1,UBE2G2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 18

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160190, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000184787, ENSG00000184900,

eachgene

Deatailed information for cohesin site CDBP00420553