- Basic information
- CohesinDB ID: CDBP00420561
- Locus: chr21-42986206-42987380
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Data sourse: GSE67783, GSE72082, GSE138405, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, ENCSR703TNG, GSE50893
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Cell type: MCF-7, GM2630, Fibroblast, Hela-Kyoto, K-562, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 64%,
"7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: GLIS1, THAP11, FOSL1, POU2F2, SMC1A, CHD8, ZNF263, EBF1, CHD2, ZFX, ZNF600, XBP1, SMAD3, WT1, FOXA1, TFAP4, ERG, RELA, CREBBP, ZNF384, NFKB2, ATF3, RUNX2, MYC, OSR2, ZNF362, HOMEZ, PRDM1, PBX4, RUNX3, GRHL3, HIF1A, CBFB, GATA3, ATF2, BATF, ZNF189, ARNT, XRCC5, FOS, IKZF1, RCOR1, ZNF143, SFPQ, NR3C1, TEAD3, KLF5, ZEB1, MYB, EZH2, TP53, ESR1, NCOA1, EVI1, MYOD1, NFKB1, JUN, RBM22, ZHX2, SPI1, CTCF, SOX5, EGLN2, IRF4, FOSL2, DRAP1, ZGPAT, JUND, BRD4, SCRT1, RELB, MAZ, FOXA3, GATAD2A, ETV5, RBPJ, EED
- Target gene symbol (double-evidenced CRMs): HSF2BP,PFKL,UMODL1,CFAP410,TRPM2,SUMO3,PKNOX1,UBE2G2,DNMT3L,RRP1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000177398,
ENSG00000160199,
ENSG00000160207,
ENSG00000160208,
ENSG00000142182,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000184787,
ENSG00000184900,
- Related loop:
chr21:34350000-34375000~~chr21:42975000-43000000,
chr21:39625000-39650000~~chr21:42975000-43000000,
chr21:42050000-42075000~~chr21:42975000-43000000,
chr21:42975000-43000000~~chr21:43325000-43350000,
chr21:42975000-43000000~~chr21:43350000-43375000,
chr21:42975000-43000000~~chr21:43575000-43600000,
chr21:42975000-43000000~~chr21:43650000-43675000,
chr21:42975000-43000000~~chr21:44250000-44275000,
chr21:42975000-43000000~~chr21:44325000-44350000,
chr21:42975000-43000000~~chr21:44800000-44825000,