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Basic information

CohesinDB ID: CDBP00420566

Locus: chr21-42996864-42997865

Data sourse: ENCSR000EFJ, GSE67783, ENCSR000HPG, GSE206145, GSE206145-NatGen2015, GSE165895

Cell type: RPE, Fibroblast, IMR-90, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 44%, "15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, XBP1, FOXA1, LEO1, ATF3, TP63, MITF, ZNF467, TRIM28, NFE2L2, OCA2, USF2, JUN, TCF12, CTCF, PAX8, IRF4, TRIM24, TEAD4, TFAP2C, EED, POU2F2, MYCN, ZNF263, DUX4, ZSCAN5A, SP4, MYC, RAD21, NKX2-1, BATF3, STAT3, RCOR1, HNRNPH1, NR3C1, CEBPB, EZH2, ZHX2, SPI1, GATA2, MXI1, MRTFB, NCOA2, SMC1A, BCL6, CEBPA, ZFX, ZNF534, SMAD3, SMARCC1, CREBBP, RUNX2, NFIB, PRDM9, FOS, SUPT5H, MED1, ZNF3, TBX5, SETDB1, RBM22, MAFK, USF1, SMC3, STAG1, FOXA2, WT1, MPHOSPH8, RELA, JUNB, BATF, MAX, ZNF143, PLAG1, NR2F2, NEUROG2, BRD2, BHLHE40, AR, EGLN2, BRD4, MAZ, ZNF24, FOSL2

Target gene symbol (double-evidenced CRMs): CFAP410,PFKL,SUMO3,HSF2BP,UMODL1,TRPM2,UBE2G2,DNMT3L,RRP1B,PKNOX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000184787, ENSG00000184900,

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Deatailed information for cohesin site CDBP00420566