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Basic information

CohesinDB ID: CDBP00420568

Locus: chr21-43000878-43004167

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 51%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ZNF468, PGR, CBX5, XBP1, FOXA1, LEO1, ATF3, NFIC, THAP1, CBFB, TP63, HDAC3, TRIM28, ZNF121, ETV1, LMO2, ESR1, OCA2, CTCF, BAF155, GATA6, ZNF714, E2F6, TRIM24, E2F1, GTF2F1, TFAP2C, EED, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, ZNF317, DUX4, ZBTB48, ZSCAN5A, DDX5, ERG2, ERG, MYC, GRHL3, GABPA, STAT3, RCOR1, DNMT3B, NR2F6, ZNF750, CEBPB, NR3C1, ESRRA, CREB1, EZH2, GRHL2, HDAC2, GATA2, HCFC1R1, RUNX1, SMC1A, CEBPA, ZNF707, CRY1, SIN3A, ZFX, POU4F2, TET2, ERG3, ZNF549, RARA, RUNX2, CDK6, ARNT, ATF2, ZNF48, SMAD4, SUPT5H, CDK8, PIAS1, SETDB1, RBM22, ASH2L, FOXP1, SMC3, STAG1, TRP47, CBX3, ZNF600, WT1, ZBTB33, HOXB13, YY1, RELA, SP140, HIF1A, MAF1, MAX, TAL1, NRIP1, ZNF143, AGO2, SPIB, NCOA3, NR2F1, KDM5B, TP53, ZNF334, ZNF765, ARRB1, AR, ZBTB26, HSF1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): U2AF1,HSF2BP,AGPAT3,RRP1B,PKNOX1,PDE9A,NDUFV3,SLC37A1,TRAPPC10

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160201, ENSG00000160207, ENSG00000160208, ENSG00000160216, ENSG00000160218,

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Deatailed information for cohesin site CDBP00420568