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Basic information

CohesinDB ID: CDBP00420570

Locus: chr21-43006547-43007242

Data sourse: GSE206145-GSE177045, GSE72082, GSE76893, GSE206145-NatGen2015, ENCSR153HNT, GSE83726, ENCSR703TNG

Cell type: K-562, RH4, Fibroblast, MCF-7

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: NIPBL,SA1,Rad21,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 49%, "4_Tx": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, MEIS2, FOXA1, PBX2, ZFHX2, TFAP4, SMARCE1, CDX2, TEAD1, ZNF217, ESR1, LMO2, CTCF, TCF12, BAF155, GATA6, DPF2, TRIM24, SOX6, E2F1, TEAD4, TFAP2C, MYCN, POU5F1, ID3, ZBTB48, STAT1, NBN, ERG2, ERG, OGG1, ETS1, MYC, SMARCA4, ARID1B, FOXP2, RAD21, GRHL3, FOXK2, STAT3, NKX3-1, IKZF1, LEF1, RCOR1, NR3C1, CREB1, FEZF1, GRHL2, HDAC2, GATA2, NCOA2, RUNX1, SMC1A, HDAC1, EZH2phosphoT487, SIN3A, ZFX, ERG3, CREBBP, RUNX2, GATA4, ARNT, PRDM9, CBFA2T3, CDK8, MED1, PIAS1, NIPBL, TFAP2A, HNF4A, CTBP2, FOXP1, PRDM6, AATF, TRP47, CBFA2T2, FOXA2, GTF2B, WT1, ESR2, FOXF1, HOXB13, KDM1A, YY1, RELA, ZNF148, SP140, HIF1A, GATA3, TAL1, MAF1, MAX, NRIP1, GATA1, ZNF143, NCOA3, NR2F2, GFI1B, NR2F1, KDM5B, PKNOX1, MYOD1, EGR2, AR, ZBTB40, EGLN2, EGR1, HSF1, NCOR1, RNF2, BRD4, ILF3, AHR

Target gene symbol (double-evidenced CRMs): PKNOX1,TRAPPC10,NDUFV3,HSF2BP,SLC37A1,PDE9A,U2AF1,RRP1B,AGPAT3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160201, ENSG00000160207, ENSG00000160208, ENSG00000160216, ENSG00000160218,

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Deatailed information for cohesin site CDBP00420570