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Basic information

CohesinDB ID: CDBP00420574

Locus: chr21-43012278-43013148

Data sourse: GSE72082, GSE138405, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EDE, GSE68388, ENCSR703TNG, GSE108869

Cell type: MCF-7, Hela-Kyoto, Fibroblast, HeLa-S3, K-562, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 75%, "5_TxWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SMC1A, CHD8, CHD2, ZFX, XBP1, ZBTB17, ZBTB48, SMAD3, WT1, FOXA1, ERG2, ZKSCAN1, RELA, CREBBP, JUNB, ATF3, NFIC, MYC, RAD21, SP140, PBX4, NFIB, DAXX, GABPA, ZNF189, STAT3, ETV6, ZNF10, FOS, ZNF143, NRIP1, DNMT3B, CEBPB, NR2F1, TP53, OCA2, ESR1, JUN, AR, HSF1, BRD4, JUND, E2F1, MAZ, TFAP2C, FOSL2

Target gene symbol (double-evidenced CRMs): NDUFV3,SLC37A1,PKNOX1,RRP1B,PDE9A,U2AF1,AGPAT3,TRAPPC10,HSF2BP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 36

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160201, ENSG00000160207, ENSG00000160208, ENSG00000160216, ENSG00000160218,

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Deatailed information for cohesin site CDBP00420574