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Basic information

CohesinDB ID: CDBP00420575

Locus: chr21-43016030-43017256

Data sourse: GSE67783, GSE86191, ENCSR000BLY, ENCSR404BPV, GSE206145-NatGen2015, ENCSR153HNT, ENCSR198ZYJ, ENCSR000EHX

Cell type: Fibroblast, HCT-116, Neurons-H1, SK-N-SH, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 49%, "5_TxWk": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, POU2F2, SMC1A, BCL6, PPARG, ZNF263, MYCN, TOP2A, CRY1, ZFX, RUNX1T1, MTA2, XBP1, DUX4, ZBTB48, WT1, FOXA1, SNAPC4, TET2, SMARCC1, TWIST1, KDM1A, RELA, HDGF, TARDBP, PBX1, CREBBP, ATF3, MYC, RFX1, RAD21, SP140, GRHL3, HIF1A, BACH1, GATA3, PRDM9, GABPA, MECOM, ZNF143, IKZF1, RCOR1, HAND2, SFPQ, NR3C1, MYOG, NCOA3, TERF1, EBF1, NR2F1, EZH2, KDM5B, ESR1, OCA2, PITX3, EVI1, EBF3, ZNF140, CTCF, SPI1, EP300, GSPT2, AR, GATA2, REST, ZSCAN29, FLI1, MXI1, BRD4, BCOR, TCF3, MAZ, AATF, SMC3, STAG1, AHR, CHD2

Target gene symbol (double-evidenced CRMs): HSF2BP,PKNOX1,RRP1B,PDE9A,SLC37A1,U2AF1,AGPAT3,NDUFV3,TRAPPC10

Function elements

Human SNPs: Biochemical_measures

Number of somatic mutations (coding): 40

Number of somatic mutations (non-coding): 20

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160201, ENSG00000160207, ENSG00000160208, ENSG00000160216, ENSG00000160218,

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Deatailed information for cohesin site CDBP00420575